The behaviour of GABA receptors is likely to be highly dependent on the local environment and this may explain many of the apparent differences between GABA receptor properties studied in situ by electrophysiological means and those studied in vitro by ligand binding techniques....
3H-flunitrazepam-labeled benzodiazepine binding sites were also increased in the striatum oriens of CA3, subiculum, and presubiculum in the hippocampus of subjects with schizophrenia (Benes et al., 1997). Quantitation of GABA receptor binding sites has also been performed in the brains of subjects...
a附件是WBS文件 The appendix is the WBS document[translate] aThe name of the asset account for the inventory items 资产帐户的名字为库存项目[translate] a水开了。 Shui Kai.[translate] aIDENTIFICATION OF GABA RECEPTOR BINDING SITES IN RAT GABA感受器官束缚位置的证明在鼠[translate]...
In attempts to identify the GABA receptor 3H-GABA has been used as ligand. 3H-GABA, however, also binds to glial and neuronal GABA uptake sites and to enzymes metabolising GABA. Thus, Na+-dependent 3H-GABA-binding2,3, in contrast to Na+-independent 3H-GABA-binding is possibly not ...
melanogaster RDL (insect GABA receptor) homo-multimer. View of the binding pocket from the parallel to the membrane plane (b), and side-on (c) and down-top (d) views of the picrotoxin-bound channel pore. Picrotoxinin, the main active ingredient of picrotoxin, is shown in ball-and-stick...
T. ( 1977 ) GABA receptor binding in rat striatum: Localization and effects of denervation . Brain Res. 136 , 501 – 511 .Campochiaro, P., Schwarcz, R. and Coyle, J. T., GABA receptor binding in rat striatum: Locali- zation and effects of denervation, Brain Research, 136 (1977) ...
The extent of the apparent neuronal loss corresponded to an increase in post-synaptic GABAA receptor sites, as assessed by the binding of [3H]muscimol to synaptic membranes. Increased [3H]muscimol binding was not accompanied by an increase in 'central-type' benzodiazepine binding sites: as ...
1999. Tagetone modulates the coupling of flunitrazepam and GABA binding sites at GABAA receptor from chick brain membranes. Mol. Membr. Biol. 16:189-194.M.A. Perillo, D.A. Garcia, R.H. Marin, J.A. Zygadlo, Tagetone modulates the coupling of Flunitrazepam and GABA binding sites ate ...
We have constructed a molecular model of the ligand-binding domain of the GABAC receptor, which is a member of the Cys-loop ligand-gated ion channel family. The extracellular domains of these receptors share similar sequence homology (20%) with Limnaea acetylcholine-binding protein for which an...
Rat [3H]Flumazenil In Vivo Binding and Plasma Pharmacokinetics of TPA023. The occupancy by TPA023 of GABAA receptor benzodiazepine binding sites in rat brain was clearly time- and dose-dependent (Fig. 1). Hence, at all three doses, maximum occupancy was observed 0.75 h after dosing, with ...