GABA-gated chloride channels: Regulation, structure and sites of gene expression in the brainMöhler H.doi:10.1007/BF01674274H.NeuroscienceMhlerNeuroscienceKluwer Academic Publishers-Plenum PublishersJournal of Protein Chemistry
4′-Ethynyl-4-n-[2,3-3H2]propylbicycloorthobenzoate ([3H]EBOB) is an improved radioligand for the noncompetitive blocker site of the vertebrate and fly γ-aminobutyric acid (GABA)-gated chloride channel. It binds with high affinity (Kd 1–4 nM) to a single, saturable site in the GABA...
GABA-gated chloride channel receptorinsect central nervous systempicrotoxin-resistant-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the cockroach central nervous system (CNS). Electrophysiological assays performed at cercal-afferent giant-interneuron (GI) synapses demonstrated that a ...
Allosteric modulation of an expressed homo- oligomeric GABA-gated chloride channel of Drosophila melanogaster. Br. J. Pharmacol. 117, 1229e1237.Hosie AM, Sattelle DB. Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster. Br J Pharmacol. 1996; ...
this study demonstrated the reduced constitutive mRNA expression of subunits of certain ligand-gated ion channels (LGIC) in the EMB resistant strain, namely a GABA-gated chloride channel subunit (GABA-Cl, ~1.4-fold decreased) and a neuronal acetylcholine receptor subunit (nAChR α-3; ~2.8-fold...
An abstract is unavailable. This article is available as a PDF only.doi:10.1097/00000542-199209001-00700Quintan, J JGallaher, E JFirestone, L LAnesthesiology
GABAA receptors are a superfamily of pentameric ligand-gated ion channels that are widely distributed in the brain [15], consisting of five subunits arranged pseudo-symmetrically around a central pore with each subunit comprising of an extracellular, intracellular, and transmembrane domain [16]. The ...
GABAAR is a heteropentameric ligand-gated ion channel of the Cys-loop family, responsible for incoming Cl− current and subsequent inhibition of neuronal excitability through hyperpolarization and decreased membrane resistivity [2,18]. To date, nineteen subunits of GABAARs have been described: α1–...
Patch-clamp recording and analysis of GABA-gated chloride currents in acutely dissociated hippocampal neurons from adult micehydroxyureanitric oxidemetabolismlivercatalasenitroxylfree radicalHydroxyurea is an approved treatment for sickle cell disease. Oxidation of hydroxyurea results in the formation of nitric...
GABA-gated chloride channels control the light adaptation of horizontal cells in the carp retinadoi:10.1016/0921-8696(94)92853-3FusaoKawaiandYoshimiKamiyamaandShiroUsuiSDOSNeuroscience Research Supplements