(1987). Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain. Brain R e . 411: 151-155.Schwartz RD, Wess MJ, Labarca R, Skolnick P, Paul SM. Acute stress enhances the activity of the GABA recep- tor-gated chloride ion channel in brain. Brain ...
The non-competitive blocker site of the GABA-gated chloride ion channel in normal susceptible strains of Drosophila melanogaster and simulans binds 4-n [ 3... AL Cole,WR Roush,JE Casida - 《Life Sciences》 被引量: 226发表: 1995年 Insecticide action at the GABA-gated chloride channel: Recogn...
GABAA receptors operate as gated chloride ion channels (see Figure 2). Binding of GABA to this receptor triggers opening of the channel, causing influx of negatively charged chloride ions into the neuron, leading to reduced excitatory neurotransmission. The mammalian GABAA receptor is comprised of ...
Several volume-gated ion channels contribute to the volume control of astrocytes. Volume-regulated anionic channels are outwardly rectifying anion channels activated by cell swelling, encoded by the SWELL1 gene, and permeable for larger anionic or uncharged molecules such as glutamate or GABA [45]....
Mostly localized to postsynaptic sites in the CNS, GABAAreceptors are GABA-gated chloride channels that belong to the Cys-loop ligand-gated ion channel superfamily. Upon GABA binding, these ionotropic receptors that are permeable to Cl-, hereby creating a short increase in the anion conductance, ...
ADrosophilamodel of sleep has been established to understand how genes, neurotransmitters, and neural activity collectively regulate sleep behaviors1,2,3. A missense mutation,minisleep(mns), in the gene encoding the evolutionarily conserved voltage-gated potassium channelShaker(Sh) has been identified ...
Ionotropic GABAA receptors are ligand-gated chloride ion channels that mediate rapid phasic inhibitory synaptic transmission, and tonic inhibition [2]. GABAB receptors are the only metabotropic G protein-coupled receptor (GPCR) among GABA receptors, which are widely expressed in mammal tissues and ...
Hue, B. (1998) A picrotoxin-resistant GABA-gated chloride channel receptor subtype in the cockroach central nervous system. Arch. Insect Biochem. Pharmacol., 37, 231±238.Jurenka, RA, Holland, D, Krafsur, ES (1998) Hydrocarbon profiles of diapausing and reproductive adult face flies (Musca ...
Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABAA receptors located in the postsynaptic membrane mediate neuronal inhibition that occurs in the millisecond ...
These pentameric ligand-gated ion channels conduct bicarbonate and chloride ions in the central nervous system of vertebrates and invertebrates. In addition, a wide range of terpenoids act as NCAs or positive allosteric modulators (PAMs) at GABAA receptors, including the monoterpenoids α-thujone and...