Insecticide action at the GABA-gated chloride channel: Recognition, progress, and prospects. Arch. Insect Biochem. Physiol. 1993, 22, 13-23.Casida JE (1993) Insecticide action at the GABA-gated chloride channel:
Mostly localized to postsynaptic sites in the CNS, GABAAreceptors are GABA-gated chloride channels that belong to the Cys-loop ligand-gated ion channel superfamily. Upon GABA binding, these ionotropic receptors that are permeable to Cl-, hereby creating a short increase in the anion conductance, ...
superior colliculus) to the cortex, visual pathways use excitatory synaptic signals (Schiller, 1986). γ-Aminobutyric acid (GABA), acting on both type A and type B receptors, is the major inhibitory transmitter in the visual system, and mediates fast synaptic inhibition by activating a ...
Casida J. E. (1993) Insecticide action at the GABA-gated chloride channel: recognition, progress, and prospects.Arch. Insect Biochem. Physiol.22, 13–23. ArticlePubMedCASGoogle Scholar Celentano J. J., Gibbs T. T. and Farb D. H. (1988) Ethanol potentiates GABA- and glycine-induced chlo...
These pentameric ligand-gated ion channels conduct bicarbonate and chloride ions in the central nervous system of vertebrates and invertebrates. In addition, a wide range of terpenoids act as NCAs or positive allosteric modulators (PAMs) at GABAA receptors, including the monoterpenoids α-thujone and...
Ionotropic GABAA receptors are ligand-gated chloride ion channels that mediate rapid phasic inhibitory synaptic transmission, and tonic inhibition [2]. GABAB receptors are the only metabotropic G protein-coupled receptor (GPCR) among GABA receptors, which are widely expressed in mammal tissues and ...
ligand-gated chloride channels that include receptors for GABA, glutamate and histamine13 and are important targets for insecticides14. In common with other members of this family of neurotransmitter-gated ion channels, five transmembrane subunits co-assemble to form a central ion channel pore, with ...
The GABAergic system involves synthesis, degradation, release, and binding of gamma amino butyric-acid (GABA), an inhibitory neurotransmitter and ion or voltage-gated calcium channel regulator, functioning at GABA receptors (Mills, 2021). From: Vitamins and Hormones, 2023 ...
The present invention features Dermacentor variabilis GABA-gated chloride channel polypeptides and nucleic acids, and uses of such polypeptides and nucleic acids.
13. A method for preparing a Xenopus oocyte expressing at least one functional lepidopteran GABA gated chloride channel which comprises injecting a Xenopus oocyte with a nucleic acid encoding, at least one lepidopteran GABA gated chloride channel, wherein the nucleic acid is selected from the group...