Caspi et al, (2005) demonstrated that polymorphisms of the gene encoding catechol-O-methyl- transferase (COMT), which is critical for the removal of dopamine (DA) in the prefrontal cortex, influenced the risk for psychosis outcomes in later life, following cannabis exposure in adolescence. Hen...
overlap with the outcomes of the candidate gene studies. With the expansion of the patient cohorts and development of more sophisticated analytical approaches, the newest GWAS data argue that diverse common alleles accumulate within a pathway and reach a threshold for susceptibility that leads to disea...
Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality... Borderline personality disorder (BPD) is characterized by a heterogeneous symptomatology with instability in impulse control, interpersonal relationships...
Cannabidiol for the Treatment of Drug Use Disorders R.G. dos Santos, ... J.A. de Souza Crippa, in Handbook of Cannabis and Related Pathologies, 2017 List of Abbreviations CB1 Cannabinoid receptor 1 CB2 Cannabinoid receptor 2 CBD Cannabidiol CNS Central nervous system COMT Catechol-O-methyl tra...
(gene replacement therapy)(诸如avxs 201);微生物调节剂(诸如ab-2004、cp-101、sb-121);神经肽受体调节剂(诸如曲芬替丁(trofinetide)、达内替德(davunetide)、nnz-2591);nmda受体激动剂或拮抗剂(诸如美金刚(memantine)、纽美仙(neramexane)、evt101、azd4282、bhv 5000);nqo1调节剂(诸如凡替醌酮(vatiquinone...
Specific polymorphisms in genes encoding for interleukins 2 and 6, catechol-O-methyl transferase (COMT), monaminooxidase B (MAO B) and several other enzymes were identified as associated with altered risks of alcoholism in humans. A polymorphism in the gene for BDNF has been linked to the ...
The catechol O-methyltransferase (COMT) gene affects how long dopamine acts in the prefrontal cortex. The Methionine polymorphism, which results in a slowe... A Diamond,L Briand,J Fossella,... - 《American Journal of Psychiatry》 被引量: 760发表: 2004年 ...