Bormann, J. and Feigenspan, A. GABAC receptors: structure, function and pharmacology. In Handbook of Experimental Pharmacology: Inhibitory Amino Acid Transmitters (Mohler, H., ed.), Springer-Verlag (in press)Bormann J, Feigenspan A (2001) GABA C receptors: structure, function and pharmacology...
对照组、EGF、GABA0.1、GABA5和GABA10分别对于伤后第2天、第5天、第7天和第10天观察创面的宏观形态 伤后第5天伤口的组织学显微照片箭头表示表皮。正常皮肤 (图a)，未处理 (图b)，EGF处理 (图C)和GABA10处理(图d)02. 让“衰老”细胞表现出“年轻”的特征 研究人员给对老年短尾猴大脑视觉皮层的神经细胞，...
研究表明TAMs起源于单核细胞（Monocytes），因此，作者们猜测GABA是通过影响单核细胞向巨噬细胞的分化来调节巨噬细胞的。为了验证这一假设，作者们将GABA加入到培养基中，发现会导致细胞数量增加、细胞存活增加同时也促进抗炎巨噬细胞特征因子FRβ（Folate receptor β）的表达。基因转录本分析也证明细胞周期相关以及叶酸...
C. E. Flores et al., Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.Proc. Natl. Acad. Sci. U.S.A.112, E65–E72 (2015). doi: 10.1073/pnas.1411170112; pmid: 25535349 S. K. Tyagarajan, J.-M. Fritschy, Gephyrin: A master regulator of neuronal function?
多种免疫细胞表达GABA系统相应组分,例如巨噬细胞表达GAD和GABA受体,T细胞表达GAD、GAT和GABA受体[3,4]。GABA系统对免疫细胞命运具有重要的影响,目前关于GABA系统(特别是GAT)免疫调控作用的研究多集中于T细胞,如GAT1缺失增强T细胞介导的免疫反...
1.GABA-receptor 4 1.GABA-receptor 5 1.GABA-receptor When 6 GABAbindstotheGABAreceptor,thesubunitsofthereceptor"open"andthereisaninfluxofchlorideions.Thisinfluxrestorestheelectricalpotentialoftheneuronandtherebydecreasesthelikelihoodthattheneuronwilldepolarizeandrelaytheincomingsignal.Essentially,weakor...
Substituting Arg104with Ala, Glu, or Lys, which experimentally disrupt GABACreceptor function, and repeating the simulation revealed fewer and different bonding patterns with GABA, or the rapid exit of GABA from the binding pocket. The simulations therefore unveil interactions of GABA within the ...
In our electrophysiological experiments, we did not observe changes in postsynaptic currents in the CeA; thus, we speculate that MG-based pharmacological manipulations may alter presynaptic GABAA receptor function, reducing GABA release at inhibitory terminals and suppressing inhibitory connections in the ...
C. Co-existent expression of GABAA receptor β2, β3 and γ2 subunit messenger RNAs during embryogenesis and early postnatal development of the rat central nervous system. Neuroscience 53, 1019–1033 (1993). CAS PubMed Google Scholar Saxena, N. C. & Macdonald, R. L. Assembly of GABAA ...
Markovian models of receptor channel activity.aSimplest Markovian model of a receptor channel, with two unitary states: open (O) and closed (C). The transition rates describing channel opening and closure are respectivelykoandkc. Both transition rates are a function of the agonist concentration [...