Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L et al (2020) Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. EMBO Mol Med 12:e10722. https://doi.org/10....
Provided are novel dipeptide repeat (DPR) specific antibodies (e.g., human-derived antibodies) as well as synthetic variants and biotechnological derivatives thereof, capable of binding C9orf72 poly-glycine-alanine DPRs, as well as methods and uses related thereto. The antibody of the present ...
Compared to quinoline-based fibroblast activation protein (FAP)-targeted radiotracers, pyridine-based FAP-targeted tracers are expected to have faster pharmacokinetics due to their smaller molecular size and higher hydrophilicity, which we hypothesize wo
中文名称 英文名称 三字母缩写 单字母符号 甘氨酸 Glycine Gly G 丙氨酸 Alanine Ala A 缬氨酸 Valine Val V 亮氨酸 Leucine Leu L 异亮氨酸 Isoleucine Ile I 脯氨酸 Proline Pro P 苯丙氨酸 Phenylalanine Phe F 酪氨酸 Tyrosine Tyr Y 色氨酸 Tryptophan Trp W 丝氨酸 Serine Ser S 苏氨酸 Threonine Thr T...
Radiolabeled somatostatin subtype 2 receptor (SST2R)-antagonists have shown advantageous profiles for cancer theranostics compared with agonists. On the other hand, the newly introduced hybrid chelator (6-pentanoic acid)-6-(amino)methyl-1,4-diazepinetria
In the ESI + mode, the metabolic pathways significantly altered by high-dose GLE treatment mainly included alpha-linolenic acid metabolism, glycine, serine and threonine metabolism, pentose phosphate pathway, riboflavin metabolism, typtophan metabolism and primary bile acid biosynthesis (Fig. 7F). In ...
欧盟HMA上市药品数据库提供Quatriga Perifer药品的基本信息,包括通用名alanine;arginine;calcium chloride dihydrate;fish oil;rich in omega;glucose monohydrate;glycine;histi,中文名丙氨酸;精氨酸;;;甘氨酸;组氨酸;异亮氨酸;亮氨酸;;;,ATC代码B05BA10 com
an amino acid residue selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tryptophan, tyrosine and valine, which amino acid residue is con...
A conserved putative dimerization GxxxG motif located in the unique membrane-spanning segment of the ATP synthase subunit e was altered in yeast both by insertion of an alanine residue and by replacement of glycine by leucine residues. These alterations led to the loss of subunit g and the loss...
Briefly, cells were cross-linked with 1% formaldehyde for 10 min, followed by incubation with 125 mm glycine for 5 min at room temperature. Cells were then lysed and sonicated 7 times for 15 s with 45 s rest between pulses at 40% pulse power using a Branson 150D Sonifier ...