Pathways for Genome Integrity in G2 Phase of the Cell Cycle. Biomolecules 2012, 2, 579-607.Kousholt, A.N.; Menzel, T.; Sorensen, C.S. Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules 2012, 2, 579-607. [CrossRef] [PubMed]...
接下来利用CellCycleScoring函数针对细胞周期阶段进行评分 object <- CellCycleScoring(object = object, g2m.features = g2m_genes, s.features = s_genes) table(object$Phase) > table(object$Phase) G1 G2M S 1197 432 1009 一共2638个细胞,每个细胞都进行了归类。 ###可视化结果 RidgePlot(object, ...
Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases. Sci. Rep. 6, 21264.Yang, D. et al. Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable ...
Cphase after M phase in which daughter cells enter new cell cycle Dall of the aboveSubmit The G0 phase Is Athe checkpoint before G1 Bthe state of most cells in an animal body Canother name for interphase Da permanent state of all body cellsSubmit Cells in G0 phase : Aterminate the ce...
A proliferating cell can become arrested in the G2 phase of the cell cycle in response to DNA damage. The arrest in G2 is mediated by the inhibition of M-phase promoting factor (MPF). The DNA damage-activated signaling pathway that inhibits the entry into mitosis is commonly known as the...
In mammalian cells, the decision to proliferate is thought to be irreversibly made at the restriction point of the cell cycle1,2, when mitogen signalling engages a positive feedback loop between cyclin A2/cyclin-dependent kinase 2 (CDK2) and the retinobl
Cdt1 regulation by FBXO31 is limited to the G2 and the early mitotic phase of the cell cycle and is independent of the pathways previously described for Cdt1 proteolysis in S and G2 phase. FBXO31 targeting of Cdt1 is mediated through the N terminus of Cdt1, previously shown to be ...
Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cyclePichierri, P.; Franchitto, A.; Mosesso, P.; Proietti de Santis, L.; Balajee, A.S.; Palitti, F.Mutation Research 459(2): 123-133...
G2/M phaseCell cyclep53/Mdm2 oscillationSystem analysisNumerical simulationIn the cell cycle, the disruption of a checkpoint control mechanism for G2/M phase which monitors DNA damages is one of the triggers for oncogenic transformation. The major event of this mechanism is the p53/Mdm2 ...
cell-cycle arrest by activating the ATM-Chk2-p53/Cdc25C signaling pathway, which inhibits the proliferation of renal cells and development of the kidney. Activation of the ATM-Chk2-p53/Cdc25C signaling pathway is the mechanism of NaF-induced renal G2/M phase cell-cycle arrest in this ...