The activity of Cdc25-like proteins is a rate-limiting step in Drosophila cell cycles as the string and twine phosphatases derepress the Cyclin-dependent kinase Cdk1 to initiate the G2/M transition. Surprisingly, overexpression of string causes cysts to form with only eight cystocytes, in ...
The study of mitotic cyclin expression during the progression of cells through G2 and M after irradiation has also revealed several possible mechanisms for induction of a G2 arrest by radiation. We found that radiation affected the control of cyclin B levels both at the mRNA level as evidenced...
英文名:CCNB3 (Cyclin B3, G2/Mitotic-specific Cyclin-B3, CYCB3) (MaxLight 405) 中文名: CBNumber:CB04967336 分子式: 分子量:0 MOL File:Mol file CCNB3 (Cyclin B3, G2/Mitotic-specific Cyclin-B3, CYCB3) (MaxLight 405)上下游产品信息 上游原料 下游产品 CCNB3 (Cyclin B3, G2/Mitotic-speci...
CCNB2, phosphorylated (S11) (CCNB2, G2/mitotic-specific cyclin-B2) (Biotin)RecommendSuppliers Recommend You Select Member Companies. Company Name:United States BiologicalRecommendComplaint Tel:1-800-520-3011 Email:sales@advtechind.com Nationality:United States ...
Finally, to limit Elg1 to G2/M phase, the promoter and N-terminal region of the mitotic cyclin Clb2 including its degrons (“G2/M-tag”) (Hombauer et al., 2011, Karras and Jentsch, 2010) was integrated upstream of ELG1. G2/M-Elg1-6HA protein was detected mainly in G2/M ...
In mammalian cells, the decision to proliferate is thought to be irreversibly made at the restriction point of the cell cycle1,2, when mitogen signalling engages a positive feedback loop between cyclin A2/cyclin-dependent kinase 2 (CDK2) and the retinobl
(KB cells, HeLa-like). S100A8/A9 expression increases PP2A phosphatase activity and p-Chk1 (Ser345) phosphorylation, which appears to signal inhibitory phosphorylation of mitotic p-Cdc25C (Ser216) and p-Cdc2 (Thr14/Tyr15) to inactivate the G2/M Cdc2/cyclin B1 complex. Cyclin B1 ...
2a,b). To ascertain the timing of mitotic entry in more detail, we analysed the expression of PLK1 and cyclin B1, which accumulate at late G2 and mitosis respectively. Moreover, we quantified the levels of cyclin B1 at different time points from three independent replicates (Fig. 4i). ...
cyclinB, and their negative regulators including p21Cip1and p27 [9]. Weakened G2/M checkpoint under therapeutic setting may trigger cell death via mitotic catastrophe for cells with unrepairable DNA lesions and mitosis machinery. This may represent a novel strategy to kill cancer cells, ...
molecules Article Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells Ying Gao 1, Junfeng Yin 1, Gary O. Rankin 2 and Yi Charlie Chen 3,* ID 1 Tea Research Institute Chinese Academy of ...