Given theQallele has been recently transferred fromB. taurustoB. indicus, GGGTTC should be the selected haplotype in European breeds and its frequency should be correlated with average body weight and size. In order to test this prediction, we explored haplotype frequencies in the Bovine HapMap d...
by Daniel C. S. Tan 1, Seonghee Jung 1, Yuanyuan Deng 1, Nicolle Morey 1, Gabriella Chan 1, Andre Bongers 2, Yazi D. Ke 1, Lars M. Ittner 1,†and Fabien Delerue 1,*,† 1 Dementia Research Centre, Department of Biomedical Sciences, Faculty of Medicine Health and Human Science...
To test the impact of the docking on the phosphorylation, we measured the Michaelis-Menten kinetics of wild-type Sli15(421–511) and the kr mutant, where the K/R residues highlighted in Figure 2B are mutated to N/Q. Mutation of the basic residues in Sli15 resulted in a profound ...
We sought to test the relative importance of the Skp2- and Cdt2-degradation pathways for bistability. Skp2 depletion leaves the bistable switch intact such that S-phase levels of p21 remain low (Supplementary Fig. 7c). However, Skp2-depleted cells show a more rapid p21 degradation prior to...