Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile...
RESEARCH Open AccessMetformin induces autophagy and G0/G1phase cell cycle arrest in myeloma bytargeting the AMPK/mTORC1 and mTORC2pathwaysYan Wang † , Wenbin Xu † , Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li and Hua Yan *AbstractBackground: Metformin is a commonly used drug for ...
Cell cycleBackground: Aegiceras corniculatum (Linn.) Blanco, commonly known as black mangrove, river mangrove, kacang-kacang, and Narikandam, is a mangrove plantdoi:10.2139/ssrn.3320140Luo, HuaHao, ErweiTan, DechaoWei, WeiXie, Jinling
沈阳出入境检验检疫局保健中心, 沈阳 110016基金项目: 国家自然科学基金资助( 30740027, 30471778)* 通信作者MEK 信号通路活化在榄香烯致人源 U87MG 胶质瘤细胞增殖抑制及G0/G1 细胞周期阻滞中的作用朱廷准1, 徐英辉2, 李晓明1, 罗力涵3, 梁国标1*[ 摘要] 目的以不同浓度榄香烯作用于人 U87MG 及 U251 ...
>40uM).Indetail,Econazole(30uM)-treatedG0/G1phasearrestinCOLO205cells,p53,p21/Cip1andp27/Kip1proteinlevelshadasignificantlyincreasebutcyclinD3,CDK4andCDK2expressedinhibitedphenomenon.Asconsequence,cyclinD3-CDK4andcyclinE-CDK2complexesactivitywasinhibitedandthusledtocellcyclearrestinG0/G1phase.Oninduction...
Fig. 4: Cell cycle shift by CsA at non-toxic doses. Full size image Enhanced crystal-cell adhesion by CsA Fig. 5: Enhanced crystal adhesion capacity of CsA-treated cells. Full size image Enrichment of S phase by HU mimicked the effect found in the repairing cell monolayers ...
Interestingly,wedemonstratedthatthepercentageofSubG1andDNAladderwerestronglypotentiatedinhumancancercellwhencombinetreatedwithketoconazolandterfenadine.Suchresultsindicatethatexcepttheoriginalfunctionofterfenadine，terfenadinehavesomeotherneweffectsresultedininduceofhumancancercellapoptosis,inhibitionofcellgrowth，andG0/G1phase...
In conclusion, RF inhibited HUVEC viability and induced cell cycle arrest (G0/G1 phase) and apoptosis via the mitochondria-mediated intrinsic pathway. In addition, RF suppressed new blood vessel formation in vivo. To our knowledge, this is the first report demonstrating that RF induces apoptosis ...
The cell cycle is a series of events related to cells in charge of cell proliferation and DNA duplication. It involves four consecutive phases, including S (DNA replication), M (nuclear division and cell division), G1 (the gap phase between M phase and S phase), G2 (the gap phase betw...
(below 80 mg/mL) was 81%. Western blotting analysis showed that WPBFE could cause the arrest of cell cycle in G0/G1 phase by down-regulating expression levels of PCNA, CDK4, cyclin D1 and up-regulating the expression level of p21. Meanwhile, WPBFE induced apoptosis through initiating ...