A., Albano, L.,Beretta, S., Calabria, A., Vavassori, V., Gasparini, P., et al. (2019).Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response.Cell Stem...
WO2006128176A2 May 26, 2006 Nov 30, 2006 Nora Llc Composite molecules comprising g-csf functionWO2006128176A2 2006年5月26日 2006年11月30日 Carter Darryl L Composite molecules comprising g-csf functionWO2006128176A2 May 26, 2006 Nov 30, 2006 Carter Darryl L Composite molecules comprising g-csf...
Huiyuan ZhangStephanie S. WatowichSpringer BaselMilestones in Drug TherapyNguyen-Jackson H, Zhang H, Watowich S. G-CSF receptor structure, function, and intracellular signal transduction. In:Molineux G, Foote M, Arvedson T, editors. Twenty years of G-CSF clinical and nonclinical discoveries. ...
G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras /mitogen-activated protein kinase (MAPK) and phosphatidylinositol...
G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been describ...
G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been describ...
G—CSF的免疫调节作用及其在异基因造血干细胞移植中的应用 制之一. 值得注意的是白细胞功能相关抗原.1(1euco. cyte?function?associatedantigen?l,LFA?1),它不仅 作为共刺激分子增强T细胞受体依赖的细胞增殖, 而且LFA.1还是初始T细胞向外周淋巴组织归巢 有关的归巢受体.G—CSF体内应用可使外周血采 集物中T细胞上...
G-CSF is cytokine that acts in hematopoiesis by controlling the production, differentiation and function of 2 related white cell populations of the blood, the granulocytes and the monocytesmacrophages. In addition, it may function in some adhesion or recognition events at the cell surface. ...
differentiation and function of 2 related white cell populations of the blood, the granulocytes and the monocytesmacrophages. In addition, it may function in some adhesion or recognition events at the cell surface. The murine G-CSF cDNA encodes a 208 amino acid (a.a.) residue precursor protein...
为引入比天然多肽至少多一个的糖链,已有人建议对hG-CSF和其它多肽进行修饰(US5,218,092)。所述多肽的氨基酸序列可以通过氨基酸取代,氨基酸缺失或氨基酸插入进行修饰以添加另外的糖链。除此之外,对天然hG-CSF的聚合物修饰,包括附着PEG基团,已有报道(Satake-Ishikawa Cell Structure and Function 17157-160,1992,US5,...