Full size table Fn14 depletion and exercise influence myofiber size We next determined if Fn14 depletion impacted myofiber size in the gastrocnemius muscle of rotarod- or grid test-trained 12-week-old WT, Fn14−/−, SOD1G93A and SOD1G93A;Fn14−/− males and females. ...
Here, we present cryo-EM structures of the active state of JSR1 in complex with Giand Gqsignaling partners. The structures provide detailed insights into the molecular architecture and conformational changes that underlie the activation of bistable opsins and their interaction with G proteins. We cha...
a Student’s unpaired two-tailt-test, a one-way analysis of variance (ANOVA) or a two-way ANOVA was used. Post-hoc analyses used are specified in Figure Legends. Outliers were identified via the Grubbs’ test. For the Kaplan–Meier survival analysis, ...
Exact test.gASCL1 and OLIG2 binding peaks at the other’s loci and known NOTCH (DLL3, NOTCH1, HES5), NSC (INSM1), and bHLH E-protein (TCF3, TCF4) targets.hDynamic co-localization of ASCL1 and OLIG2 in PDOX-GBM. Percentage co-localization of ASCL1 and OLIG2 was previously rep...
Irradiation with 365 nm visible light converted compound L1 into the closed version L2 (Table 1, entry 1). Preliminary results obtained on the antiparasitic activity of L1 and L2 against T. cruzi Y strain were in the range of that found for first-line drug Bzn. These results encouraged us...
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Blood platelet adhesion experiment shows similar trends obtained from protein adsorption test. As shown in Fig. 8 and Table 2 (The data listed in Table 2 are average values calculated from every seven SEM pictures of each sample), a large number of platelets are found on the pure polycyclooct...
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1). Two unnatural amino acids that contain α-methyl, α-alkenyl side chains were introduced into the peptide and the staple covalently formed by Grubbs’ 2nd-generation catalyst-catalyzed ring-closing metathesis9. Table 1. Physicochemical properties of the designed stapled peptides. PeptideSequence...