Amgen has been a pioneer in developing and delivering G-CSF therapy and launched NEUPOGEN in 1991.1 Structure and pharmacokinetics Human G-CSF produced by recombinant DNA technology2 Elimination half-life: approximately 3.5 hours2 Clearance Primarily renal clearance3 Dosing Daily G-CSF injections2 ...
The body makes G-CSF The body makes a natural protein called G-CSF, which acts in the bone marrow to boost the production of white blood cells called neutrophils.NEUPOGEN® is a form of G-CSFLike G-CSF, NEUPOGEN® acts in the bone marrow, where it helps boost the production of ...
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ProductTelpegfilgrastim injection (PEG G-CSF) Pegylated Human Granulocyte Colony-Stimulating Factor Trade name: PEGNEUGEN Technology:Recombinant gene technology, expressed by Yeast Amino acid:175 amino acids; Non-glycosylated Molecular weight:Approximately 59 kD (MS molecular weight) Indications:Neutropenia...
Shi Q, Hodara V, Butler SD, Thomas CA, Hubbard GB, VandeBerg JL et al. Differential bone marrow stem cell mobilization by G-CSF injection or arterial ligation in baboons. J Cell Mol Med 2009;13:1896-1906.Shi Q,Hodara V,Butler S D,et al.Differential bone marrow stemcell mobilization ...
(2.6), which results in its almost complete ionization and very low lipid–water partition coefficient at pH 7.4. When the meninges are inflamed, the concentrations obtained in CSF are around 5% of the plasma level. In uremia, accumulated organic acids may enter the CSF and compete for ...
GM-CSF release from A549 cells was inhibited by dexamethasone (EC50 = 2.2 nM). The concentration-dependent ability of dexamethasone (EC50 = 36 nM) to induce transcription of the beta2-receptor was found to correlate with GR DNA binding and occurred at 10-100 fold higher concentrations than th...
Reimund KP, Weitzel F, Lorenz W, et al (1995) G-CSF prophylaxis and treatment in postoperative peritonitis: Animal experiments and a successful case report. In: Faist E (ed) The immune consequences of trauma, shock, sepsis mechanisms and therapeutic approaches (in press) Google Scholar Sarto...
Pavone V, Gaudio F, Guarini A, Perrone T, Zonno A, Curci P, Liso V (2002) Mobilization of peripheral blood stem cells with high-dose cyclophosphamide or the DHAP regimen plus G-CSF in non-Hodgkin’s lymphoma. Bone Marrow Transplant.;29(4):285– 90. https://doi.org/10.1038/sj....
Inc All rights reserved 0023-6837/15 G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice Yuji Guo1, Shangming Liu1, Xianghong Zhang1, Liyan Wang1, Jiangang Gao2, Aiqing Han3 and Aijun Hao1 Granulocyte colony-stimulating factor (G-CSF) was investigated...