艾贝格司亭α注射液作为第三代长效G-CSF,实现长效、强效的同时具有较好的安全性和便捷性,可作为这类患者的优选药物。 刘丽宏教授:中性粒细胞减少症严重影响肿瘤患者的临床治疗和生存,长效G-CSF药物是近年来“升白药”的主流,一直以来,预防及治疗中性粒细胞减少症存在巨大的未被满足的临床需求。随着新一代长效G-CSF...
严重肝、肾、心、肺功能障碍者、骨髓中幼稚粒细胞未显著减少的骨髓性白血病患者或外周血中检出幼稚粒细胞的骨髓性白血病患者也禁用。 在使用PEG-G-CSF注射液时,应遵循以下注意事项:首先,应在化疗药物给药结束48小时后开始使用,并勿在使用细胞毒性化疗药物前14天注射。其次,使用过程中应定期监测血常规,不低于每周2次...
短效G-CSF主要经肾脏清除,而以艾贝格司亭α注射液为代表的第三代长效G-CSF具有高稳定性、低免疫原性,和更强的药物活性,而且使用更为便捷。其结构上的创新优化降低了过敏等不良反应的发生率。既往研究显示,艾贝格司亭α注射液在高危风险的化疗方案下能有效地维持中性粒细胞的数量。与PEG-rhG-CSF相比,艾贝格司亭...
Granulocyte colony-stimulating factor (G-CSF), also known as colony-stimulating factor 3 (CSF3), is a proinflammatory cytokine that primarily stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. Over the past years, G-...
USP Drug List: Letter G Here is a small sample listing of generic, non-prescription, prescription, and OTC (over-the-counter) pharmaceuticals.The total list, from A-Z, is over 12,000 non-prescription, generic, OTC (over-the-counter), and prescription pharmaceutical names. The list is by...
binding with its receptor expressed by cardiomyocytes after an ischemic injury, directly activates prosurvival signaling.25Although G-CSF has been consistently confirmed in experimental animal models to act as a regenerative and cardioprotective drug af...
The drug is widely distributed in most tissues and body fluids. Highest levels are found in the kidney, with lower levels in the liver, skin and intestines. Low concentrations appear in saliva and in maternal milk. It does not enter uninflamed bone or the CSF. Its entry is limited by its...
The FDA approved drug granulocyte-colony stimulating factor (G-CSF) displays anti-apoptotic and immunomodulatory properties with neurogenesis and angiogenic functions. It is known to demonstrate neuroprotective mechanisms against ischemic global stroke. Autophagy is a method for the degradation of intracellula...
give to the public give up because of he give up drug habits give up the practice give you some colour give your client a pe give your name give your rejoice give to charity givea once-over givepay lip service t givemeyourhandbygeorg given a cool get toer given cool-has toer give...
Close Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma. Email address Sign up I agree my information will be processed in accordance with the Nature and Springer Nature Limited Privacy Policy....