G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric effects, and biased signaling or balanced signaling, characteri...
其细胞质部分可以与三聚体G蛋白相互作用,其胞浆面第三个环能与鸟苷酸结合蛋白(G蛋白)偶联,通过不同的G蛋白影响腺苷酸环化酶或磷脂酶C,改变细胞内第二信使浓度,以实现跨膜信息传递。此类受体通过G蛋白向下游传递信号,因此又称为G蛋白偶联受体。结果一 题目 G蛋白偶联受体?(G protein coupled receptor) 答案 在...
[名词解释] G蛋白耦联受体(G-proteincoupledreceptor) 相关知识点: 试题来源: 解析 一种与三聚体G蛋白耦联的细胞表面受体。含有7个穿膜区,是迄今发现的最大的受体超家族,其成员有1000多个。与配体结合后通过激活所耦联的G蛋白,启动不同的信号转导通路并导致各种生物学效应。
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism Article Open access 23 September 2023 References Rask-Andersen, M., Almen, M. S. & Schioth, H. B. Trends in the exploitation of novel drug targets. Nature Rev. Drug. Discov. 10, 579–590...
氢作为宇宙最基本的元素,氢离子/质子也是自然界最小的配体,目前已经发现细胞外的质子能激活许多离子通道,例如酸敏感离子通道ASIC(acid-sensing ion channel)、氯离子通道、双孔钾通道、瞬时受体电位通道TRP(transient receptor potential)家族成员和酸味感知通道OTOP1(Otopetrin 1)。有意思的是,作为另一大类的细胞膜蛋白...
Objective To study the function and mechanism of G protein coupled receptor kinase interacting protein 1(GIT1) RNA hairpin (GIT1-RNAh) in osteoblast migration. Methods The sixth passage osteoblasts were divided into 2 groups and were infected by GIT1-RNAh (experimental group) and green fluores...
G protein-coupled receptors (or GPCRs) represent the largest family ofmembrane proteinsin the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas th...
G protein-coupled receptor human (GCREC) and, the invention provides polynucleotides encoding identify GCREC. The present invention also, I also provides antagonist expression vectors, host cells, antibodies, and agonists. The present invention also provides methods of diagnosing, treating or ...
G protein-coupled receptor homologous desensitization is intrinsically related to the function of a class of S/T kinases named G protein-coupled receptor kinases (GRK). The GRK family is composed of six cloned members, named GRK1 to 6. Studies from different laboratories have demonstrated that di...
[名词解释] G-protein linked receptor (G-蛋白偶联受体) 相关知识点: 试题来源: 解析 配体与受体结合后激活相邻的G-蛋白,被激活的G-蛋白又可激活或抑制一种产生特异第二信使的酶或离子通道,引起膜电位的变化。由于这种受体参与的信号转导作用要与GTP结合的调节蛋白相偶联,因此将它称为G蛋白偶联受体。 这类受体...