此外,脆弱拟杆菌还能通过抑制FXR-NLRP3信号通路来减轻NEC。 参考文献 :Chen Z, Chen H, Huang W, et al. Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway.Gut Microbes. 2024;16(1):2...
Moreover, FXR activation abolished the ability of ER stress to decrease the expression of Nck1, leading to the inhibition of inflammasome activation and cell death. MiR-186 was identified as a repressor of Nck1 and involved in ER stress-mediated NLRP3 inflammasome activation. Overall, our ...
patterns.Conclusion (1) Primary conjugated bile acids increased in patients with liver fibrosis; (2) GCDCA induce hepatic fibrosis via the NLRP3 inflammasome pathway; (3) FXR inhibits NLRP3 activity by restraining its phosphorylation; (4) knockdown or knockout of NLRP3 may relieve the onset of...