We hypothesize that although bile acids and FXR signaling are potent mediators of metabolic function, unidentified downstream targets are the main mediators behind the benefits of weight-loss surgery. One of these targets, the gut-derived peptide FGF15/19, is a potential molecular and ...
FXR-FGF19 肠肝轴:一种新的肝属性 马振增 陆伦根 作者单位: 200080 上海 上海交通大学附属第一人民医院消化科 肝实质细胞死亡或者部分肝叶切除后,触发肝脏异常强大 的再生能力,当肝脏受到内外源性毒素的损伤时,这种再生能 力可以保护肝脏,从而保持全身代谢稳定 ...
篇名 FXR-FGF19肠肝轴:一种新的肝属性 来源期刊 肝脏 学科 关键词 年,卷(期) 2016,(4) 所属期刊栏目 热点论坛 研究方向 页码范围 304-306 页数 3页 分类号 字数 2608字 语种 中文 DOI 作者信息 序号姓名单位发文数被引次数H指数G指数 1 陆伦根 上海上海交通大学附属第一人民医院消化科 5 18 2.0...
Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcriptional control of numerous enterohepatic genes, including intestinal FGF19, a hormone that strongly represses hepatic BA synthesis. How activation of th
This study investigated key intersections of the FXR-FGF19 pathway along the gut鈥搇iver axis and their link to disease severity in patients with cirrhosis.Methods Patients with cirrhosis undergoing hepatic venous pressure gradient measurement (cohort-I n?=?107, including n?=?53 with concomitant ...
Farnesoid X receptor (FXR)Fibroblast growth factor 15 (FGF15)Fibroblast growth factor 19 (FGF19)Non-alcoholic steatohepatitis (NASH)The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the ...
elsevierGastroenterologyAVILA, M.A., and MOSCHETTA, A. (2015). The FXR-FGF19 Gut-Liver Axis as a Novel "Hepatostat." Gastroenterology 149: 537-540.Avila MA, Moschetta A. The FXR-FGF19 gut-liver axis as a novel "hepatostat" [J] . Gastroenterology, 2015, 149(3):537-540....
(FXR-FGF19) axis.ConclusionsOur studies implicated that intestinal FXR is responsible for the regulation of lipid metabolism in diet-induced dyslipidemia mediated by gut microbiota-bile acid crosstalk.27dVNVWG4xVHYhT6VNwbbKVideo AbstractConclusionsOur studies implicated that intestinal FXR is responsible...
Objective To investigate the effect of Quzhi Ruangan prescription on the farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) pathway in rats with nonalcoholic steatohepatitis (NASH). Methods Male Sprague-Dawley rats were randomly divided into normal ...
菌和肺炎克雷伯菌.ERCP取石术后6个月,患者血清LPS,FGF19水平明显降低,CYP7A1水平明显升高(P均<0.05),益生菌干预组数据变化较对照组更为显著(P均<0.05).结论:口服益生菌制剂可降低胆固醇结石高危人群的血清LPS水平,同时调节胆汁酸经肠肝循环代谢的经典通路法尼酯X受体(FXR)-FGF19通路,从而减少胆汁中的胆...