FVII gene polymorphismlower extremity deep venous thrombosisR353QThis study aims to explore the associations between FVII gene polymorphisms (R353Q, 5′F7, and 402G/A) and lower extremity deep venous thrombosis (LEDVT) in a Chinese Han population. LEDVT patients (153) and healthy people (174)...
1)FVII geneFVII基因 1.The results show that there are no significant differences in genotype distribution and allele frequencies of ACE gene,FVII gene, ICAM-1 gene in Uighur patients with CHD when compared to healthy subjects (P>0.结果显示,冠心病组与健康对照组相比,ACE基因、FVII基因、ICAM-1基...
Factor VII Deficiency: Clinical Manifestation and Molecular Genetics of 718 Subjects with FVII Gene MutationsThe congenital Factor VII deficiency (FVIID) is a rare hemorrhagic disorder with an autosomal recessive pattern of inheritance and a prevalence of 1:500,000. Since 1994 we investigated in the...
一种优选转染方法是电穿孔,也可以使用其它方法,包括磷酸钙共沉降、月旨质体转染和微注射等。电穿孔方法应用设置为250V电压和1050 μ Fd电容的Gene PulserElectroporator (Bio-Rad Laboratories),放置在比色杯内的2~3 X IO7个细胞中加入20 yg PvuI线性化的表达质粒,电穿孔后的细胞转移至含30ml生长培养基的摇瓶中...
Cloning and characterization of the rat cytochrome P450 4F5 (CYP4F5) gene. PMID: 12384299 Renal consequences of preterm birth. PMID: 28101838 1-[(2,3,4,5,6-Penta-fluoro-phen-yl)ethyn-yl]ferrocene. PMID: 21588152 Development of Fluorescence Polarization Immunoassay With scFv to Detect Fumonisi...
Cloning and characterization of the rat cytochrome P450 4F5 (CYP4F5) gene. PMID: 12384299 Renal consequences of preterm birth. PMID: 28101838 1-[(2,3,4,5,6-Penta-fluoro-phen-yl)ethyn-yl]ferrocene. PMID: 21588152 Development of Fluorescence Polarization Immunoassay With scFv to Detect Fumonisi...
TF has the potential to activate STAT5 through JAK when regulating the gene expression of its targets. Normal transcriptional targets of STAT5 are known to include Bcl-2. Also, previous studies showed that the Bcl-2 gene promoter contains a STAT5 consensus element, and that STAT5 is able to...
此外,两款靶向B细胞成熟抗原(BCMA)的CAR-T疗法有望获批治疗复发/难治性多发性骨髓瘤。其中,BMS和bluebird bio联合开发的idecabtagene vicleucel(ide-cel)已经获得FDA授予的。杨森和传奇生物联合开发的CAR-T疗法ciltacabtagene autoleucel(cilta-cel)在去年底也已。
Scarpati, et al., "Human Tissue Factor: cDNA Sequence and Chromosome Localization of the Gene", Biochemistry vol. 26, No. 17, pp. 5234-5238 (1987). Fischer, et al., "Cloning and Expression of Human Tissue Factor cDNA", Thrombosis Research vol. 48, No. 1, pp. 89-99 (1987). ...
The gene organisation and protein structure of FVII are similar to those of other vitamin K-dependent procoagulant proteins, with exons 1a and 1b encoding for signal sequence; exon 2 the propeptide and Gla domain; exon 3 a short hydrophobic region; exons 4 and 5 the epidermal growth factor-...