Li-Fraumeni syndrome is a rare yet serious hereditary cancer predisposition syndrome, marked by a significant early-life increased risk of developing cancer. Primarily caused by germline mutations in the TP53 tumor suppressor gene, Li-Fraumeni syndrome is associated with a wide range of malignancies. ...
Figure1ashows the Absolute GWP (AGWP) calculated for H2and decomposed into its different contributions. Rather than focusing on a particular time-horizon, we estimate and show the AGWP as a function of the time-horizon. The total AGWP increases with the time-horizon, reaching a maximum value...
in one case, possibly phyllostomid bats. The paradigm of arenaviruses exclusively infecting small mammals shifted dramatically when several groups independently published the detection and isolation of a divergent group of arenaviruses in captive alethinophidian snakes...
For example, the targeted delivery of fusogenic lipid-coated porous silicon nanoparticles containing small interfering RNA to activated M1-type macrophages can specifically silence their interferon regulatory factor 5 (IRF5) gene to preserve the bactericidal capacity of the cells, effectively block the ...
Cardiometabolic disorders were originally thought to be driven primarily by changes in lipid metabolism that cause the accumulation of lipids in organs, thereby impairing their function. Thus, in the setting of cardiovascular disease, statins — a class
(C) Cytoplasmic flagellin activates caspase-1 and secretion of IL-1β via NLRC4/NAIP5-dependent inflammasome pathway. (D) CpG-ODN interacts with TLR9 in the endosome and recruits MyD88 and the downstream molecules, which activates either NF-κB or IRF7 according to the type of endosomes. ...
This method has been proven effective at identifying groups of drugs that share common targets. When drugs with predicted shared targets did not in fact have known targets in common, the predictions provided a framework for testing these drugs for binding against each other's targets. Hence, ...
We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and inflammaging. This approach has the potential t
Psychological aspects of human nature cause behavioural biases and can lead to decisions that differ from what is expected based solely on rational analysis. The effects of behavioural biases on financial markets like stocks and mutual funds have been st
(gfttee)idrmeienasneidaltwyedafjisliansoncedgeetdo-snrwwtaestteciutmohhrnaneetvaawerviini(tenhtrs)dae θ=ngoeow laobonsgsfaie as(lrylPfvlsiixsae(tttdeoi)do)cth nkt−oess dT = 5 trading days: therefore, adjacent time windows share a significant number of ...