No treatment has been found to alter the natural course of disease in patients with PSC except for liver transplantation. Identifying PSC patients at risk of developing cholangiocarcinoma (CCA) is another unmet need. Current research in all AILD including AIH, PBC and PSC, focuses on improving ...
Viridian Therapeutics is leveraging core expertise in antibody discovery to develop optimized treatments for rare autoimmune conditions
In a recent study published inCell, Wang X et al.1reported the first use of allogeneic anti-CD19 CAR T cells in patients with therapy-resistant autoimmune diseases, demonstrating their effectiveness in reducing disease activity, with good tolerability and persistence. These findings suggest that allo...
Autoimmune hepatitis is a chronic inflammatory liver disease. Unknown triggers lead to a mainly T cell-mediated immune response targeting the liver, the main auto-antigen of which has not been identified yet. The diagnosis of autoimmune hepatitis is based on the elevation of immunoglobulin G/hyper...
Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting approximately one in 300 individuals in the United States. The majority of genetic research to date has focused on the heritability that predisposes to islet autoimmunity and T1DM. The evidence so far points to T1DM being a polyge...
Or an X-ray? Is this coughing a sign of autoimmune disorder? Or in the end, does the patient actually just hope to get a note from a doctor that they can show to their employer? 99% of healthcare delivery is figuring out what a patient really and truly needs. ...
autoimmune diseases, and rare diseases. What we see as remarkable today is going to pale in comparison to what comes next, such as unlocking genomic and regenerative medicines for currently intractable common diseases, like Parkinson’s and Alzheimer’s Disease. What really excites me is thinking ...
Autoantibodies can be found in autoimmune diseases and cancer [98], and have been shown to be useful biomarkers of disease as well as give information relating to inflammation in patients with autoimmune disease [97]. Autoantibody testing has been shown to be successful in the earlier detection ...
90 However, excessive accumulation of inflammatory cytokines could induce tissue necrosis or exacerbate the onset of autoimmune diseases.91 Therefore, identifying the correct strategy to employ immunomodulatory materials to rapidly eliminate bacteria while reducing inflammatory damage to tissues and promoting ...
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. Here, we review the remarkable progress made over the past 20 years in improving the potency and specificity of small-molecule inhibitors of...