Most sarcoma subtypes are associated with mutations that result in constitutive activation of pro-survival and growth-factor signaling pathways (Fig.4). These include the platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), c-KIT and c-MET path...
The impact of adversity can thus lead to distinct outcomes, with some individuals being categorised as at-risk and others as stress-adapted [136]. These observations underscore the heterogeneity in the impact of adversity, emphasising the need to shift from group-level inferences to individual-leve...
Introduction—The basic features of the current stratified medicine strategy in cancer The current status of stratified medicine platform programmes in cancer Combination targeted therapy—The essential need for accurate modelling of the toxicity–activity trade-off of combinations Agent selection—The essenti...
Genomic selection of dairy cattle : A review of methods, strategies, and impact Dairy Cattle Selection in the Pre-genomic ERA. J Anim Breed Genomics. 2017;1(1):1–15. Google Scholar Xu Y, Liu X, Fu J, Wang H, Wang J, Huang C, et al. Enhancing Genetic Gain through Genomic ...
The new Scopus CiteScore formula and the Journal Impact Factor: A look at top ranking journals and middle ranking journals in the Scopus categories of General Physics and Astronomy, Materials Science General Medicine and Social Sciences, 43 (2020), pp. 739-748 CrossrefView in ScopusGoogle Schola...
The integrative approaches in natural products research also promote progress toward the precision medicine paradigm. While most of this kind of study remains at the early stage, limited by phenomenon observation and the lack of in-depth mechanistic investigation, it represents an important direction ...
Homelessness and emergency medicine: a review of the literature. Acad Emerg Med. 2018;25(5):577-593. doi:10.1111/acem.13358PubMedGoogle ScholarCrossref 10. Tsai J, Doran KM, Rosenheck RA. When health insurance is not a factor: national comparison of homeless and non...
Intellectual disability (ID) can be caused by non-genetic and genetic factors, the latter being responsible for more than 1700 ID-related disorders. The broad ID phenotypic and genetic heterogeneity, as well as the difficulty in the establishment of the
The Wolfson Centre for Personalized Medicine and Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, UK Munir Pirmohamed Corresponding author Correspondence to Munir Pirmohamed. Ethics declarations ...
et al. Integrative analysis of drug response and clinical outcome in acute myeloid leukemia. Cancer Cell 40, 850–864.e9 (2022). Article CAS PubMed PubMed Central Google Scholar Kornauth, C. et al. Functional precision medicine provides clinical benefit in advanced aggressive hematologic cancers...