The fused proteins in one species mimic important phenomena such as operon-like structures, protein subunit interaction, multiple functionalities, and alternative splicing in another species. These observable facts are discussed using suitable examples. The significance of fusion proteins in molecular ...
Recently, artificial fusion proteins have also been constructed as novel protein switches in some synthetic biology applications (Grünberg and Serrano, 2010). In addition, recombinant fusion proteins, such as engineered antibody fragments, have become a new class of therapeutic agents (Schmidt, 2013)...
Pina AS, et al. (2014) Affinity tags in protein purification and peptide enrichment: An overview. Methods in molecular biology (Clifton, N.J.) 1129: 147-168. Kosobokova EN, et al. (2016) Overview of fusion tags for recombinant proteins. Biochemistry (Mosc) 81(3): 187-200. ...
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of small conserved eukaryotic proteins that mediate membrane fusion between organelles and with the plasma membrane. SNAREs are directly or indirectly anchored t
Proteins systematically undergo self- and co-assembly to yield short- and long-range ordered nuclei, substrates and other cellular organelles, as well as to catalyze reactions. The precise molecular recognition and the self-assembly exhibited in these interactions are an outcome of evolutionary process...
Nature Cell Biology volume 25, pages 323–336 (2023)Cite this article 10k Accesses 64 Altmetric Metrics details Abstract Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation, ...
Furthermore, E6 proteins are generally cysteine-rich. E6 proteins contain two zinc-binding domains, each involving four cysteine residues to coordinate one zinc ion. In addition to these eight cysteine residues highly conserved for structural purposes, E6 proteins contain additional non-conserved ...
A key element of membrane fusion reactions in biology is the involvement of specific fusion proteins. In many viruses, the proteins that mediate membrane fusion usually exist as homotrimers. Furthermore, they contain extended triple-helical coiled-coil domains and fusogenic peptides. It has been ...
This invention relates to non-cytotoxic fusion proteins, and to the therapeutic application thereof. Toxins may be generally divided into two groups according to the type of effect that they have on a target cell. In more detail, the first group of toxins kill their natural target cells, and...
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are