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FER-1 and the ferlin protein family are membrane proteins with four to seven C2 domains. These domains commonly mediate Ca2+ -dependent lipid-processing events. Most of the fer-1 mutations fall within these C2 domains, showing that they have distinct, non-redundant functions. We found that ...
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The tremors of Parkinson's disease usually occur first in a single extremity body part (finger, hand, foot) that is at rest in about 70% of patients; the tremor usually stops when the body part is in use by the person. The tremor is fast (4 to 6 cycles per second that shakes rhyth...