1d). Our data suggest that La’s tight regulation during osteoclastogenesis is likely carried out at the protein level, as M-CSF derived precursors contain even more La transcript (gene SSB) than after RANKL application (Fig. S1e). When La returns in RANKL derived, fusogenic osteoclasts, it ...
Presence of the V5/C3 epitope in EMPEM correlated with autologous neutralization activity that was subsequently reduced or eliminated by introducing a PNGS into the V5 loop at position 46527,52. The gp120/gp120-interface antibodies were not seen in previous EMPEM analysis in animals immunized with...
23 June 2021 © CERN for the benefit of the ATLAS collaboration 2021 Abstract The paper presents a measurement of the Stan- dard Model Higgs Boson decaying to b-quark pairs in the vreescptoorndbionsgotnof1u2s6iofnb−(V1 BofF√) psro=du1c3tiToenVmporodteo.nA–psraomtopnlecoclolri-...
In contrast to the downstream helical domains (amino acids 29–40 and 43–57), the N-terminal α-helix of Myomerger (amino acids 5–25) is long enough to span the bilayer (Figure S3A). To test if Myomerger is an integral membrane protein, we fractionated membranes from WT C2C12 ...
at least as long as the sterile males are living. This is especially true when the sterile males have a competitive advantage over the wild-type fertile ones. Moreover, the cells of the non-human animals of the invention can also be used to generate recipient embryos useful for the generati...
The temporal bone has a tight relationship with two small structures: the ear ossicles (maellus, incus, and stapes) and the styloid process (tympanohyal part and stylohyal part). The former structures develop partially embedded within the temporal bone, while the latter structures fuse with ...
This is critical because mating takes many hours and the cytosols and genomes of the mating partners are already mixed in the diploids long before the daughter cell emerges. As a consequence, the diploids can express both pro-ALP and PEP4 and deliver them to the nascent daughter that serves...
Instead, we chose a threshold that was slightly larger (in absolute value) than the root mean squared (rms) noise that reflected the smallest pores that could meaningfully be measured (~0.2 nm, the size of a hydrated Na+ ion, corresponding to ~16 pS assuming a 15 nm long ...
Binding sites of TBHQ are formed by the residue of the long α-helix of one protomer and the short α-helix of a neighboring protomer (Figure 5). Interactions of TBHQ with HA are mostly of hydrophobic nature, as the binding site is saturated with hydrophobic amino acids: L129, L298, ...
Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Biol. Reprod. 2003, 68, 1597–1612. [CrossRef] [PubMed] 101. Yu, W.; Ruest, L.B.; Svoboda, K.K. Regulation of epithelial-mesenchymal transition in...