Fungal MDR outbreak: Candida aurisNosanchuk, JoshNosanchuk, Josh
The rise in antimicrobial resistance has become a major threat to public health1. Although the focus has primarily been on pan-resistant bacteria, there is growing concern over the multidrug-resistant fungal pathogen,Candida auris. This emerging pathogen has galvanized researchers, health care workers,...
The issue is further proliferated by the increasing number of emerging fungal pathogens including MDR Candida auris, Fusarium spp. and Mucorales (Yousfi et al., 2019). Additionally, rare and emerging moulds including Lomentospora spp. and Scedosporium species have innate AMR and represent a ...
Among the NRRL 32931 LS genes, we observed a striking expansion of the PacC/Rim1p family (Fig.4a), the members of which encode highly conserved fungal transcription factors that mediate signaling in response to ambient pH35,36. In human pathogenic fungi such asCandida albicans37,Cryptococcus neo...
auris infection has been reported that is one of the rare factors in IC. This species, which is known as an emerging global health threat, cause a higher degree of mortality and indicates the intrinsic multidrug-resistant (MDR) relative to triazoles, echinocandins, and polyenes [[26], [27]...
invasive acute and subacute infections and lead to massive drug resistance. The different species ofCandida, i.e.,C. albicans,C. krusei,C. auris, andC. tropicalis,are placed in critical-priority and high-priority groups, respectively. WHO identifies antibiotic-resistant microorganisms (ARM) and ...
Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents. Antimicrob. Agents Chemother. 2022, 66, e0005322. [Google Scholar] [CrossRef] [PubMed] Briano, F.; Magnasco, L.; Sepulcri, C.; Dettori, S.; Dentone, C.; Mikulska, M.; Ball, L.; Vena, A.; Robba, C.; ...
auris, as well as on other non-albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing. Keywords: fungal biofilm; antifungal resistance; natural products; Candida spp.; ...
The finding that the UVC disinfecting system used in the current study was active against the vegetative cells of Candida auris and the spores of Aspergillus niger is therefore of importance, especially as these are often difficult to kill with other chemical or UV disinfection systems [74]. The...
Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model. Microbiol. Spectr. 2021, 9, e0001321. [Google Scholar] [CrossRef] Arias, L.S.; Butcher, M.C.; Short, B.; McKloud, E.; Delaney, C.; Kean, R.; Monteiro, D.R.; Williams, C...