ON THE FUNCTIONS AND USES OF THE THYMUS GLAND.ON THE FUNCTIONS AND USES OF THE THYMUS GLAND.. By - H.G. Wrightdoi:10.1016/S0140-6736(02)88437-9WrightH.G.Elsevier Ltd.Lancet
Its main role in the immune system is to produce specialized T cells that target foreign pathogens or cancer cells. What are some disorders of the thymus gland? Thymus cancers are rare but include thymoma and thymic carcinoma, the latter of which is harder to treat. DiGeorge syndrome is a ...
When damage happens, you may notice symptoms like chest pain, since your thymus gland is in your chest. Shortness of breath and weight loss are other symptoms of a problem with your thymus. These symptoms may be a sign of an autoimmune condition or potentiallythymus cancer. There are other ...
They are important for normal embryonic development and are involved in diseases such as cancer. Both histones and non-histone proteins are targets for the histone demethylases. Examples of non-histone substrates include p53, DNA methyltransferase 1 (DNMT1) and E2F1. Histone demethylase activity is...
In this Review, we consider evolving insights into the tissue distribution of eosinophils and their functional immunobiology, which enable eosinophils to secrete in a selective manner cytokines and other mediators that have diverse, 'non-effector' functions in health and disease. This is a preview ...
Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative...
cancer. Data from epidemiologic, animal and clinical studies collectively support preventive functions of THs in liver-related diseases, highlighting the therapeutic potential of TH analogs. Elucidation of the molecular mechanisms and downstream targets of TH should thus facilitate the development of ...
Thyrotropin-releasing hormone (TRH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. This was employed in the TRH stimulation test, which is currently little used. The role of TRH as a cancer biomarker is minor,...
With the technical advances of the past few decades, there has been increasing emphasis in neurophysiology and neuropharmacology on studies at the cellular and subcellular levels, as illustrated by most of the chapters in the present volume. The magnitudes and sequences of the electrical signs associ...
Evidence has accumulated suggesting that melatonin, the major endocrine product of the pineal gland - as a well-preserved molecule through evolution - is involved in the feedback between neuroendocrine and immune functions. At present, we are beginning t