Estrogen is the main sex hormone produced by the ovaries. It exists in many forms, however, estradiol is the most abundant and potent version of estrogen. Estrogen diffuses across cell membranes to bind to estrogen receptors and activate many genes related to sexual characteristics. Estrogen is ...
Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroe... Y Hojo,TA ...
Estradiol (E2) is important for male skeletal health and the effect of E2 is mediated via estrogen receptor (ER)-α. This was demonstrated by the findings that men with an inactivating mutation in aromatase or a nonfunctional ERα had osteopenia and continued longitudinal growth after sexual ...
This review will reconsider the role of ubiquitination in E2:ERα signaling by particularly highlighting how the functions of the non-degradative ubiquitination impact on ERα activities and contribute to the modulation of E2-dependent physiological processes. 展开 关键词: 17β-Estradiol Estrogen ...
Progesterone plays a central coordinate role in regulating reproductive events associated with the establishment and maintenance of pregnancy including ovu
[137]. The overexpression of NLRP3 by 17β-estradiol (E2) inhibits the development of hepatocellular carcinoma cells, indicating that NLRP3 may play a protective function in hepatic malignancy [138]. The data imply that NLRP3 plays a tumor suppressor role in colorectal cancer [22]. The NLRP...
The inhibition of autophagy initiation by 3-Methyladenine (3-MA) promoted smooth autophagic flow, thereby partially reduced the secretion of estradiol and progesterone by KGN cells; Whereas blocking autophagic flux by Rapamycin (RAPA) further exacerbated the secretion of estradiol and progesterone in ...
Regulation of adipose tissue 1α-hydroxylase by phosphorus, parathyroid hormone, calcitonin, estradiol, pro-inflammatory cytokines, phytoestrogens or other factors is an interesting topic for research. It is well established that 1α,25(OH)2-D3 stimulates its own degradation by induction of the 24...
[182] reported a significantly higher incidence of anovulation and luteal defects in a group of regularly menstruating DS women, while showing reduced estradiol plasma concentrations along the cycle and lower progesterone levels in the mid-luteal phase. In a follow-up study, the authors administered...
This developing follicular cohort initiates the synthesis and secretion of another hormone,estradiol, which has a reverse regulatory function: it acts on the pituitary and blocks FSH production. Follicular phase of the menstrual cycle and action of FSH ...