The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity.Ouyang WKolls JKZheng YImmunityOuyang W, Kolls JK, Zheng Y: The biological functions of T helper 17 cell effector cytokines in ...
Functions of T cells in asthma: more than just TH2 cells Asthma has been considered a T helper 2 (T(H)2) cell-associated inflammatory disease, and T(H)2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13, are thought to drive the disease pathology in patients. Although...
The germinal center reaction is a key event of humoral immunity, providing long-lived immunological memory. Follicular helper T (TFH) cells are a specialized subset of CD4+T cells located in the follicles, which help B cells and thus control the germinal center reaction. TFHcell development is...
King, C. New insights into the differentiation and function of T follicular helper cells. Nature Rev. Immunol. 9, 757–766 (2009). Article CAS Google Scholar Huber, S. A., Graveline, D., Newell, M. K., Born, W. K. & O'Brien, R. L. Vγ1+ T cells suppress and Vγ4+ T...
The role of macrophages in the in vitro induction of T helper cells Nature, 254 (1975), pp. 352-354 CrossrefView in ScopusGoogle Scholar Waldron et al., 1973 J.A. Waldron, R.G. Horn, A.S. Rosenthal Antigen-induced proliferation of guinea pig lymphocytes in vitro: Obligatory role of ...
CD4+ T-cells: Cluster of differentiation 4+ T cells (CD4+) are mature T-helper cells which express the surface protein CD4. They recognize the peptides found on antigen-presenting cells (APCs). Answer and Explanation:1 The functions of CD4+ T cells are- ...
maturation, and functions of immune cells, including T, B, dendritic, and myeloid cells. This review also discusses the underlying relevance of disruption of SUMO cycling and site-specific interruption of SUMOylation on target proteins in immune cells in diseases, including cancers and infectious di...
Activation and differentiation of T-helper (Th) cells into Th1 and Th2 types is a complex process orchestrated by distinct gene activation programs engagin... Kartiek,Kanduri,Subhash,... - 《Genome Medicine》 被引量: 4发表: 2015年 Generation of BCR-ABL Reactive CD4+ T Helper Cells By ...
T helper 17 (Th17) cells are important mediators of immune responses against extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining mucosal homeostasis. Conversely, Th17 cells and their effector molecules interleukin 17A (IL-17A), IL-17F, interferon (IFN)γ, ...
Type I IFNs mediate the regulatory functions of dendritic cells in the gut and the protective effect of TLR ligands in colonic injury. Activation of type I IFN signalling has an important role in T helper cell differentiation and in the suppressive function of regulatory T cells. Type I IFNs...