aProteins play a major role in ensuring your overall wellbeing. There are innumerable functions of proteins in the body. The primary functions of proteins include building and repairing of body tissues, regulation of body processes and the formation of enzymes and hormones. 蛋白质在保证您的整体福...
Protein is an important part of a healthy diet. It is used to repair damage in the body, and therefore very important for nutrition. What are the functions of proteins in cells? Proteins are responsible for many processes in cells. These processes include building cellular structures, disposing...
Artificial receptors introduced in the proximity of the active site can modulate the structures and activities of native proteins in response to specific guest molecules. This concept has been expanded to include flavoenzymes such as glucose oxidase. An immense variety of non-natural molecules a...
Crucial to the functions of the ER are the ER-resident proteins in the ER lumen [2]. A major component of these ER-resident proteins includes the protein disulfide isomerases (PDIs), a class of multi-domains, multi-functional enzymes that belongs to the thioredoxin superfamily. The PDI famil...
Methylation of nonhistone proteins affects protein stability, cellular localization, protein‒protein interactions, promoter binding affinity, and the regulation of other posttranslational modifications on the substrates (Fig. 1b). Fig. 1: Characteristics of protein lysine methylation. a The process of...
Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates telomerase-dependent telomere extension. Mice possess two functionally distinct POT1 proteins. POT1a repr
The broad spectrum of TNF-mediated biological functions is a direct consequence of its ability to induce the expression of a large number of gene products. Genes or proteins that can be induced by TNF include transcription factors (e.g., c-fos and c-jun), cytokines (e.g., IL-1, TNF,...
Exosomes are tiny extracellular vesicles secreted by most cell types, which are filled with proteins, lipids, and nucleic acids (non-coding RNAs, mRNA, DNA), can be released by donor cells to subsequently modulate the function of recipient cells. Skin ph
Viral proteins carry out functions that are critical for infection. Some proteins or their component domains are widely conserved within and across viral families, including between viruses of distinct Baltimore classifications4 and in viruses that infect different kingdoms of life5,6. These include ‘...
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER associated stress proteins are molecular chaperones essential for cellular homeostasis. The major functions of HSPs include chaperoning misfolded or unfolded polypeptides,