By guiding chromatin modification, RNAi components promote chromosome segregation during both mitosis and meiosis and regulate chromosomal and genomic dosage response. Small RNAs and the RNAi machinery also participate in the resolution of DNA damage. Interestingly, many of these lesser-studied functions ...
Cytokinins are a set of hormones that influence growth and the cell cycle in plants. The name 'cytokinin' comes from the fact that they modulate cell division (cytokinesis) or mitosis. Regulation of mitosis influences growth processes from the growing phase of seed germination to the declining ...
Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and dire
HumansNeoplasmsran GTP-Binding ProteinMitosisThe Ran GTPase has important roles in nucleocytoplasmic transport, cell cycle progression, nuclear organization and nuclear envelope (NE) assembly. In this review, we discuss emerging evidence that implicate the Ran GTPase system in mitotic control in mammalian...
Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these kinases have unique functions in mitosis. Within the polo-like kinase family, the emphasis for targeted therapies has be...
[167]. The anticancer mechanisms of MTAs have focused mainly on their ability to disrupt cancer cell mitosis, thereby inhibiting tumor cell proliferation. Recently, it was discovered that they can also significantly increase cancer cell stiffness and enhance Piezo2 signaling responses [167,168]. ...
[181]. cIGF1R encodes the antitumor peptide C-IGF1R that interacts with VDAC1, resulting in reduced ubiquitination of VDAC1 and limiting mitosis in NSCLC cells in the EGFR-TKI drug-tolerant persister (DTP) state [182]. Sorafenib is a multikinase inhibitor. One study suggested that circZKSaa...
(NLRs). There are 14 members of this protein subfamily in humans (called NLRP1 to NLRP14). NLRP3 and NLRP4 are examples of inflammasome receptors that offer adjuvant effects to activate the adaptive immunity pathway. However, there are other NLRPs that can also form inflammasomes, such as ...
Functions regulated at least in part by endocytosis include: signal transduction, membrane composition, mitosis, adhesion, lipid homeostasis, motil- ity, and cell morphogenesis. Distinct forms of endocyto- sis have evolved in eukaryotes, with clathrin-mediated endocytosis (CME) being the most well-...
inCrb1C249Wmice [27]. In addition, it significantly downregulated the transcriptional levels of retinal pituitary tumor transforming gene 1 (Pttg1) [27].Pttg1is a securin originally found in pituitary tumors [55]. It can inhibit the premature segregation of sister chromatids during mitosis and...