Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol 2014; 7: 90.Loewen G, Jayawickramarajah J, Zhuo Y, Shan B. Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. (2014) 7:90. doi: 10.1186/s13045-014-0090-4...
HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development via targeting HOXA1 gene expression. We and others have previously shown that myeloid-derived suppressor cells (MDSCs), a heterogeneous...
Commonly, dysregulation of lncRNAs exerts impacts on cellular functions such as cell proliferation, resistance to apoptosis, induction of angiogenesis, promotion of metastasis, and evasion of tumor suppressors [8], [17]. Table 1. Examples of lncRNAs in cancer lncRNADescriptionRefs. PTCSC3 ...
Here, we showed that GIAT4RA, a poorly characterized lncRNA LOC102723729, was significantly decreased in lung cancer cells and tissues; while no association was observed with clinical risk factors, expression was linked with clinical stage and lymphatic metastasis. Higher expression of GIAT4RA was ...
This study was implemented to figure out whether lncRNA HOTAIR/miR-17-5p/PTEN axis played a role that was opposite to Shenqifuzheng (SQFZ) injection in regulating the chemosensitivity of gastric cancer cells. The gastric cancer tissues were gathered and four gastric cancer cell lines were prepar...
Sun X, Li Q, Yang L. Sevoflurane inhibits lncrna hotair-modulated stability of hk2 mrna in a m6a-dependent manner to dampen aerobic glycolysis and proliferation in lung cancer. Biomed Res Int 2022. 2022;2022:4668774.https://doi.org/10.1155/2022/4668774. ...
In the HOTAIR/miR-330 pathway, HOTAIR (lncRNA) upregulation can play an oncogenic role through the interaction with miR-330, which leads to the initiation and progression of GC via induction of PI3K/Akt signaling pathways [62]. Accordingly, downregulation of HOTAIR and overexpression of miR-...
It is commonly assumed that gastrointestinal cancer is the most common form of cancer across the globe and is the leading contributor to cancer-related death. The intricate mechanisms underlying the growth of GI cancers have been identified. It is worth
Long non-coding RNA (lncRNAs) are defined as a heterogeneous class of mRNA-like transcripts that are longer than 200 nucleotides but without protein-coding ability [3,16]. Similar to mRNAs, their transcription is also involved in RNA Polymerase II (RNAPII), and most of the lncRNAs are poly...
This work uses tiling microarrays to discover hundreds of non-coding RNAs transcribed from HOX gene clusters, focusing on HOTAIR, which regulates HOX gene expression in trans on distant chromosomes. Article CAS PubMed PubMed Central Google Scholar Geisler, S. & Coller, J. RNA in unexpected ...