RNA polymerase synthesizes RNA from DNA that is functionally for protein-coding (messenger RNA, mRNA) or non-coding (RNA genes). Because of these functions, RNA molecules are of following types: messenger RNA (mRNA) –It is the RNA that carries information from DNA to the ribosomes (site ...
Highly stable nucleic acid structure formed in guanine (G)-rich regions by the stacking of at least two G-tetrads, each of them corresponding to a square-shaped association between four guanines. Rights and permissions Reprints and permissions About this article Cite this article Bourgeois, C.,...
RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure
We used the trained SVM model to make predictions for each lncRNA in the independent dataset. Each lncRNA is corresponding to several possible GO terms, and the score of each GO term is between 0 and 1. The higher the score, the more confident the prediction is. Therefore, we need to ...
Each type of gastric cancer has its own characteristics, and each gastric cancer patient can be effectively treated clinically through molecular targeting therapy [55]. Researchers have found a link between SMAD2 and USP32. SMAD2 is a key element of transforming growth factor signaling pathway in ...
The ORF1 product strongly resembles beta-hydroxyacyl-CoA dehydrogenases of bacteria and mammals and the ORF2 and ORF4 products resemble each other and enoyl reductases from bacteria, animals, and plants, with a highly conserved cofactor-binding domain. These findings strongly suggest that the actVI...
Three replicate RNA samples of each type were used to prime cDNA synthesis and amplification, with a slightly modified protocol for embryo sac and ovule tissue, due to the limited amount of starting material. We constructed libraries and produced paired-end and single-end sequence reads on the ...
Samples in each group were located far from the other group samples in the gene expression PCA plot, which suggested that the RNA-seq quality was good. However, one sample of group 3 was located far from the other samples of group 3 in the gene expression PCA plot, for which this study...
Type I IFNs are implicated in different autoimmune and inflammatory conditions, although their role in each condition varies. Some autoimmune diseases are improved by the biological effects of type I IFNs, whereas others benefit from type I IFN inhibition. Abstract Interferon-α (IFNα) and IFNβ...
(d) The expression levels (log2(FPKM + 0.1)) of expressed protein-coding genes (blue) and lncRNAs (red) in each cancer type. Full size image Differentially expressed lncRNA genes We defined differentially expressed genes between the tumor samples and matched normal samples based on the ...