Yin et al. on the functions of deoxyribonucleic acid (DNA) polymerase (Pol) ε published within the issue. The researchers have identified a nonlethal mutation of Pol2a in Arabidopsis that causes an abscisic acid (ABA) overly sensitive phenotype, suggesting a link between DNA Pol ε activity ...
Gain an understanding of DNA polymerase and RNA polymerase. Learn what DNA polymerase does and explore the functions of RNA primase and their end...
Archaeal DNA replication machinery represents a core version of that found in eukaryotes. However, the proteins essential for the coordination of origin selection and the functioning of DNA polymerase have not yet been characterized in archaea, and they are still being investigated in eukaryotes. In ...
DNA polymerase III reads the nucleotides on the template strand and makes a new strand by adding complementary nucleotides one after the other. For eg., if it reads an Adenine on the template strand, it will add a Thymine on the complementary strand. ...
The final phosphodiester linkage between the 5’-phosphate group on the DNA chain synthesized by DNA polymerase III and the 3’-hydroxyl group on the chain made by DNA polymerase I is catalyzed by DNA ligase. The most organism requires energy for the cleavage ofATPand NAD+. Energy is require...
Identification of an Intrinsic 5\"-Deoxyribose-5-phosphate Lyase Activity in Human DNA Polymerase ?: A POSSIBLE ROLE IN BASE EXCISION REPAIR Base excision repair (BER) is a major repair pathway in eukaryotic cells responsible for repair of lesions that give rise to abasic (AP) sites in DNA....
Functions of the poly(ADP-ribose) polymerase superfamily in plants. Rebecca S. Lamb,Matteo Citarelli,Sachin Teotia. CELLULAR AND MOLECULAR LIFE SCIENCES . 2012Lamb RS, Citarelli M, Teotia S (2012) Functions of the poly(ADP-ribose) polymerase superfamily in plants . Cell Mol Life Sci 69 ...
M. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity. J. Biol. Chem. 286, 10690–10701 (2011). Reports the structure of most of human PARP1 in complex with a model substrate for...
Poly(ADP-ribose) (PAR) is synthesized from NAD+by PAR polymerases (PARPs) and regulates many physiological processes such as the maintenance of DNA integrity, gene expression and cell division. PARPs form a superfamily of 17 members in humans, and display diverse subcellular distributions and func...
These functions include endocytosis/exocytosis, ionchannel modulation, DNA polymerase inhibition, and regulation of gene expression. These new discoveries will enable us to reexamine the underlying mechanisms for the classical symptoms of essential fatty acid deficiency as well as vitamin E deficiency. ...