In this article, we consider a new robust estimation procedure for functional linear models with both slope function and functional predictor approximated by functional principal component basis functions. A mo
regression_l1,加了l1正则的回归,等同于绝对值误差 regression_l2,等同于均方误差 huber,Huber Loss fair,Fair Loss poisson,泊松回归 分类 binary,二分类 multiclass,多分类 排序 lambdarank 模型 boosting gbdt,传统的梯度提升决策树 rf,随机森林 dart,Dropouts meet Multiple Additive Regression Trees goss,Gradient-...
The introduction of mutations in highly scored phosphosites is also expected to cause important functional consequences. We curated information on protein gain and loss of function as a consequence of 1,092 mutations affecting phospho-acceptor residues (Methodsand Fig.4c). In line with our expectatio...
We built a robust linear regression model using the “rlm” function in R, with five covariates: i.e., mRNA expression values of three ADAR genes (ADAR, ADARB1, and ADARB2), tissue, region, group, and individual. P-values were computed using the Wald test in the sfsmisc R package ...
Forests harbor extensive biodiversity and act as a strong global carbon and nitrogen sink. Although enhancing tree diversity has been shown to mitigate climate change by sequestering more carbon and nitrogen in biomass and soils in manipulative experimen
Functional capacity was assessed using the UHDRS (TFC, IS, and FCS) [21,36]. The TFC ranges from 0 to 13, with 13 being normal and 0 being a complete loss of capacity. IS score range from 0 to 100, 0 representing no need and 100 indicating bedridden/tube fed. The FCS consists of...
B, t1/2s for missense phPAI-1 variants determined using massively parallel kinetics were compared with those described for recombinant PAI-1 both in this study and previously reported (49). A linear regression (slope = 0.5, R = 0.8) indicates a strong positive correlation between our massively...
The linear regression trendline (black) and its 95% confidence interval (shaded gray area) are shown in the scatter plots. Source data Full size image Another interesting hit was the positive correlation of PIP4K2C_2 thermal stability with cell line sensitivity to the MDM2 inhibitor idasanutlin...
We identify 14 genes with functional involvement in osteoarthritis pathogenesis, including the homeobox gene Pitx1, and functionally characterize 6 candidate human osteoarthritis genes in mouse models. We demonstrate sensitivity of the methods by identifying age-related degenerative joint damage in wild-...
We hence focused on the 19q13.12 event, which resulted in the loss of a copy of ZNF382—a tumor suppressor and repressor of c-Myc42. Application of scNOVA measured significantly increased activity of ERCC6—a target gene of the c-Myc/Max transcription factor (TF) dimer43—and decreased ...