In this article, we consider a new robust estimation procedure for functional linear models with both slope function and functional predictor approximated by functional principal component basis functions. A modified Huber's function with tail function substituted by the exponential squared loss (ESL) ...
rTIMP-1 and the mutant proteins purified from WiDr:mock retained wild-type levels of inhibitory activity, whereas T-WT from WiDr:GnT-V showed a significant loss of gelatinase inhibition. The inhibition of gelatinases by TIMP-1 was confirmed by gelatin zymography (Fig. 5C), where the gelatin...
Forests harbor extensive biodiversity and act as a strong global carbon and nitrogen sink. Although enhancing tree diversity has been shown to mitigate climate change by sequestering more carbon and nitrogen in biomass and soils in manipulative experimen
Here, univariate regression analysis showed a significant increase in TNF-α in BD hCS for all time points. TNF-α regulates apoptotic cascades [67], which may be related to neuronal loss, potentially explaining the reduction in neurons in BD hCS compared to CTRL hCS. Moreover, Li treatment ...
together with some loss of surface lamina (Fig.4, Supplementary Fig.5and Supplementary Data4). No osteophytes were detected inBhlhe40−/−mice (Supplementary Data8).Bhlhe40is a widely expressed transcription factor involved in regulation of cell proliferation, differentiation, apoptosis, and senes...
The linear regression trendline (black) and its 95% confidence interval (shaded gray area) are shown in the scatter plots. Source data Full size image Another interesting hit was the positive correlation of PIP4K2C_2 thermal stability with cell line sensitivity to the MDM2 inhibitor idasanutlin...
In this study, we performed genome-scale loss-of-function (LOF) screens with the clustered regularly interspaced short palindromic repeats (CRISPR) technology to identify mechanisms of resistance of multiple myeloma (MM) cells to degronimids targeting the bromodomain and extraterminal (BET) bromodomain...
This eliminates the problems of collinearity and the linear dependence within our features and allows for a robust representation of feature importance. Assessing these classifiers showed both false negatives (Additional file 1: Fig. S14C) and positives (Additional file 1: Fig. S14D). False ...
aLinear regression analysis ofSTAMBPL1andSNAI1expression from TCGA cancer datasets for LUAD and BRCA.bTumour genomic RNA-seq expression data from 107 human lung adenocarcinoma and breast cancer cell lines analysed for expression correlation ofSTAMBPL1withSNAI1using the CCLE dataset with indicatedRandp...
Mice heterozygous for a Foxn1 allele with a single nucleotide loss at position 1470 (designated FOXN1Δ505/WT) were generated at the Genome Engineering Facility of the MRC Weatherall Institute of Molecular Medicine, University of Oxford as previously described35. Rag2−/− mice were bred and...