该工具可与Kegg数据库集成,用于进一步的功能富集分析。 Kegg功能富集分析的应用还包括了其他类型的功能注释和功能预测。例如,研究人员可以根据输入基因列表中的GO (Gene Ontology)注释信息,进行GO功能富集分析。GO是一种常用的基因和蛋白质注释分类系统,它提供了一个标准化的词汇来描述基因和蛋白质的功能、过程和组件。
Then, the candidate genes sharing the same or similar functions with known disease genes in the 【functional enrichment 】analysis of GeneOntology and KEGG databases as final disease genes were determined.基于基因功能一致性和其在蛋白质互作网络中的拓扑属性将基因与疾病之间建立关联,对疾病风险...
In addition to GO analysis, functional enrichment analysis can also be performed using other public databases and resources such as KEGG pathways, Reactome, and Disease Ontology. These resources provide curated annotations and pathways that can be used to identify statistically significant overrepresentatio...
1)functional enrichment功能富集分析 1.Then, the candidate genes sharing the same or similar functions with known disease genes in thefunctional enrichmentanalysis of GeneOntology and KEGG databases as final disease genes were determined.基于基因功能一致性和其在蛋白质互作网络中的拓扑属性将基因与疾病之间...
Both gene ontology (GO) and KEGG pathway enrichment analysis are major processes for investigating gene groups that participate in common biological responses or possess related functions. However, traditional approaches based on differentially expressed genes only detect a few significant GO terms and ...
4). Similarly, pathway analysis of the SMR-FI network revealed cell cycle and cell death processes, with particularly strong enrichment of immune regulation processes, with 9 of the top 20 pathways (Additional file 2: Table S8) and 14 of the top 50 GO-Biological processes linked to immune ...
(n = 11, GO: 0045202,p = 1e−08), neuron projection (n = 9, GO: 0043005,p = 2e−05), and neuroactive ligand–receptor interaction (n = 5, KEGG: 04080,p = 2e−04). Detailed information on individual genes and references to the original studies are...
Functional enrichment analysis of DLGAP5 To gain insights into the underlying mechanisms by which DLGAP5 contributes to the poor prognosis of LUAD, we conducted GO/KEGG analysis and identified a total of 442 DEGs, including 260 downregulated genes and 182 upregulated genes (Fig. 7A). The top...
g, h, Enrichment for co-annotated gene pairs included in the co-similarity network derived from genes significant in at least three screens and time points using the KEGG and CORUM databases. i, Functional enrichment for co-annotated gene pairs within clusters across various cluster number ...
GO analysis of the screened 17K-interacting genes. The genes were divided into three categories: cellular component, biological process, and molecular function genes. Full size image Figure 4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for the 17K-interacting host genes...