Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly but differentially contribute to the fine regulation of movement. However...
Zebrafish is used as a model vertebrate in over 1,200 laboratories worldwide for studies of organismal, cell and gene function in development, regeneration, behavior, toxicology and disease modeling. Its popularity is due to its experimental advantages1, convenient genetic manipulation tools, wide-ran...
those that perform functions intransand propose an experimental approach to dissect lncRNA activity based on these classifications. These strategies to further understand lncRNAs promise to reveal new and unanticipated biology with great potential to advance our understanding of normal physiology and disease...
Unless the center sensitivity is selectively depressed, the responses of spectrally-opponent neurons mimic those of spectrally non-opponent cells and show neither spectral nor spatial opponency. The classifications of cell types often have implicit or explicit underlying assumptions about the functional ...
In a new study, researchers were able to generate functionally mature motor neurons from induced pluripotent stem (iPS) cells, which are engineered from adult somatic cells and can differentiate into most other cell types. A potential new source of motor
Genetic testing is widely used in evaluating a patient’s predisposition to hereditary diseases. In the case of cancer, when a functionally impactful mutation (i.e. genetic variant) is identified in a disease-relevant gene, the patient is at elevated ris
Based on the conduction velocity and on classifications of mammalian nerve fibers (18), for the two CAP components of rat SN, we suggest that the first consists of contributions of Aa fibers (50-120 m/s) and the second consists of Ab and Ac fibers (15-70 m/s) (19...
Conclusions: Abnormalities in TMS-derived motor maps cut across the clinical classifications of hemiplegic and diplegic CP. The lateralization of the upper and lower extremity motor representation demonstrates reorganization after insults to the affected hemispheres of both diplegic and hemiplegic children....
The specificities of the two strategies were high (100% and 98.7%, respectively), whereas neither of the sensitivities were more than 20%. Fig. 3: Visualization of classification by SVM analyses. A The accuracy, sensitivity, and specificity of the classifications of patients with recurrent MDD ...
A maximum probability atlas defining all of the major lobes and subcortical ROIs of the brain was warped to match each subject, and the intersection of this atlas with GM and WM classifications yielded striatal ROI masks including the caudate and putamen which were used to analyze the DAT ...