Mapping functional brain networks Identifying functional networks of areas showing highly correlated fMRI signals is critical to characterizing the brain architecture. Using the independent component analysis (ICA), a data-driven approach for separating independent patterns in multivariate data, we identified...
Optical recordings of neuronal activity at cellular resolution represent an invaluable tool to investigate brain mechanisms. Zebrafish larvae is one of the few model organisms where, using fluorescence-based reporters of the cell activity, it is possible to optically reconstruct the neuronal dynamics acro...
Differentiation of human pluripotent stem cells to small brain-like structures known as brain organoids offers an unprecedented opportunity to model human brain development and disease. To provide a vascularized and functional in vivo model of brain organoids, we established a method for transplanting ...
Schematic map ofMCPH1protein domains labeled with lineage-specific amino acid substitutions.Sites containing human specific substitutions are marked with shadows, and the two dramatic brain size enlargement events that coincided with the molecular signatures of Darwinian positive selection during primate evolu...
A. Detre, "Assessment of functional development in normal infant brain using arterial spin labeled perfusion mri.," Neuroimage, vol. 39, pp. 973-978, Feb 2008.Wang Z, Fernandez-Seara M, Alsop DC, Liu WC, Flax JF, Benasich AA, Detre JA (2008) Assessment of functional development in ...
In any non-trivial software application, there are countless potential test scenarios, and it’s rarely feasible to test everything exhaustively. Instead, effective testers focus their efforts on the areas of highest risk, where defects would have the most severe impact on users or the business....
Finally, we employed magnetic resonance imaging (MRI) to monitor the volumetric alterations in the hippocampal and cortical brain areas in aged mice. The hippocampus and cerebral cortex play key roles in learning, memory and executive functions, and these brain regions are particularly vulnerable to ...
In this study, alterations in brain activation changes during reward processing and at rest in MDD patients compared with healthy subjects are explored and the effects of a single low dose of the dopamine D2 receptor antagonist amisulpride are investigated. Methods This is a randomized, controlled,...
Ideally, elucidating the role of specific brain circuits in animal behavior would require the ability to measure activity at all involved synapses, possibly with unrestricted field of view, thus even at those boutons deeply located into the brain. Here, we introduce and validate an efficient scheme...
Brain function relies on communication between large populations of neurons across multiple brain areas, a full understanding of which would require knowledge of the time-varying activity of all neurons in the central nervous system. Here we use light-sheet microscopy to record activity, reported thro...