R.H.G. assisted in the modelling and validation of structures. B.W.H. performed the LAD2 mast cell degranulation assay. B.J.B. assisted in the structure modelling. J.K. supported agonist discovery and optimization for MRGPRX4. S.T.S. performed the GPCRome assay. B.E.K. designed ...
The first high-resolution structure of a retroviral intasome reveals the IN–viral DNA architecture underlying DNA recombination as well as the mechanism of clinical INSTI action. CAS PubMed PubMed Central Google Scholar Guan, R. et al. X-ray crystal structure of the N-terminal region of ...
It is easily derived that the resulting estimator of β has the same structure as 2, with Ω replaced by P. A convenient property of P-splines is that they are numerically stable and very easy to define and implement. In particular, it is much easier to set up the difference matrix D ...
physiology and leukemia. Moreover, WT-MLL1 has been found to be essential for MLL1-rearranged (MLL1-r) leukemia. Rigorous studies of such PPIs have been performed and much progress has been achieved in understanding their structures, structure–function relationships and the mechanisms for activati...
Secondary structure elements are shown above the sequence (dark blue, α helices; light blue, 310 helices; green, β strands; black dots every tenth residue). Highlighted amino acids act in binding FAD (green) and MTHF (5,10-methenyltetrahydrofolate) (yellow). The regions where Synechocystis...
Structure-Function Studies with the Unique Hexameric Form II Ribulose-1,5-bisphosphate Carboxylase/Oxygenase (Rubisco) from Rhodopseudomonas palustris. R. Structure-function studies with the unique hexameric form II Ribulose-1,5- bisphosphate carboxylase/oxygenase (Rubisco) from Rhodopseudomonas palustris. ...
A crystallographic protein structure determination was required to eventually transfer the concept of a biological prismane-like cluster to the realm of fables [2]. 2.2. Nomenclature The name prismane has remained to be associated with the Hcp up to this day, for example in annotations, by ...
However, targeting the human ribosome in the case of protein synthesis deregulations such as in highly proliferating cancer cells has not been investigated at the molecular level up to now. Here we report the structure of the human 80S ribosome with a eukaryote-specific antibiotic and show its ...
structure and potential functional of microbial communities in 645 wetland soil samples globally, we examined the potential role of archaea, bacteria, and fungi in nitrogen (N) cycling and N2O emissions. We show that N2O emissions are higher in drained and warm wetland soils, and are correlated ...
. This intrinsic meaning is necessary for using the model in computations. In order to exploit the results of such computations for the explanation of biological phenomena the model needs also a biological interpretation: the model possesses an extrinsic meaning relating its structure, its ...