of USP18 on the impact of Treg cell differentiation and function.We found that USP18 deficiency upregulates the differentiation of Treg cells,which may lead to disrupted homeostasis of peripheral T cells,and downregulates INF-y,IL-2,IL-17A producing CD4^(+)T cells and INF-纬producing CD8^(...
Treg cells require the phosphatase PTEN to restrain TH1 and… 热度: FunctionofmiR-146ain ControllingTregCell-Mediated RegulationofTh1Responses Li-FanLu, 1 MarkP.Boldin, 2,6 AshutoshChaudhry, 1 Ling-LiLin, 1 KonstantinD.Taganov, 2,6
Thus, it is extremely important for cancer prevention to understand the involvement of dietary components with the early stage dynamics of interactions among these immune cells. This review addresses the potential significance of diet in supporting the function of NK cells, Treg cells, and the ...
The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss of function or induced ablation of Treg cells results in a fatal autoimmune disease featuring all known types of inflammatory responses with every manifestation...
Using a lentiviral system to express exogenous Sirt2 in Treg cells, we found that Sirt2 weakened the anti-inflammatory effect of Treg cells on pro-inflammatory macrophages. Additionally, post-MCAO microglia increased Sirt2 expression in Treg cells in a cell-to-cell contact manner. We further ...
RESULTS. Although no significant differences were observed across the three serial measurements of the number or function of the Treg cells analyzed (p>0.05 in both cases), a substantial proportion of individuals showed notable changes (either an increase or decrease) in these parameters during the...
One important aspect of mesenchymal stromal cells (MSCs)-mediated immunomodulation is the recruitment and induction of regulatory T (Treg) cells. However, we do not yet know whether MSCs have similar effects on the other subsets of Treg cells. Herein, we studied the effects of MSCs on CD8+CD2...
Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells. CD4(+) CD25(+) regulatory T (Treg) engage in the maintenance of immunological and homeostasis by limiting aberrant or excessive inflammation. The transcrip... Y Gao,F Lin,J Su,... - 《...
We identified a signature of TGFβ signaling within granuloma-infiltrating T cells in both mice and rhesus macaques. Selective blockade of TGFβ signaling in T cells resulted in an accumulation of terminally differentiated effector CD4 T cells, improved IFNɣ production within granulomas, and ...
However, whether ATLL cells actually function as Treg cells has not yet been clearly demonstrated. Here, we show that ATLL cells from a subset of patients are not only hypo-responsive to T-cell receptor-mediated activation, but also suppress the proliferation of autologous CD4+ non-ATLL ...