1 , to suggest that thiamine may play a vital part in peripheral neurophysiology that is independent of its classical role as a coenzyme. Experiments in our laboratory suggest that thiamine may function as a neurohumour in the central nervous system, and, in addition, may be involved with ...
function of the microbiome, the sum of associated microorganisms. Microbiome composition changes with age with conflicting reports of increased diversity in the elderly [6], possibly indicating a loss of control mechanisms, but also of reduced diversity [7,8,9], which is associated with numerous d...
Cells were grown in the absence of thiamine to induce full expression from the nmt1 promoter and production of β-galactosidase from each Gα-transplant strain was assayed using ONPG as a substrate. (A) Cells expressing Mam2 were exposed to no ligand (blue columns), 1 μM P-factor (red...
In addition, peanut butter contains thiamine. Studies show that thiamine helps improve glucose utilisation by the brain. Furthermore, it is crucial for enzyme secretions that help maintain healthy brain functions. Peanut butter also contains high protein, which helps form neurotransmitters that help ...
Thiamine pyrophosphate Glycosylation Transport Uptake Mutation 1. Introduction Thiamine (vitamin B1) is indispensable for oxidative energy (sugar) metabolism and ATP production in the mitochondria via its role as a cofactor (mainly in the form of thiamine pyrophosphate; TPP) for multiple enzymes (transk...
He received thiamine and lipoic acid therapy, the de- tails of which are reported elsewhere [19]. No major therapeutic response occurred. The patient was first shown to have proximal RTA at the age of 12 months, and a more detailed evalua- tion of his renal function was made at 32 ...
Heart failure (HF) is a complex clinical syndrome that represents a major cause of morbidity and mortality in Western countries. Several nutraceuticals have shown promising clinical results in term of HF prevention as well as in the management of symptoms associated to the early stages of the dise...
[35]. These seemingly conflicting findings might be due to strain differences and the genusLactobacillusencompasses many different strains. Furthermore, in line with the improved physiological parameters, the yMB microbiome encoded higher activities of folate and thiamine metabolism, which are established ...
The gut whilst performing digestive functions is also a primary portal for symbiotic, commensal and parasitic organisms; and in general, chemical, physical and innate immune barriers prevent invasion against the majority of these. The human gut is colonized by trillions of symbiotic bacteria that perf...
We thus constructed PM-anchored Scs2 (hereafter referred as Scs2-PM) by replacing its C-terminal TM domain with a PM targeting motif (“KKKKKKSKTKCVIM”) from human K-Ras4B28 and ectopically expressed it under the strong thiamine (Thi)-repressible nmt1 or pi11 promoter in scs2Δscs22Δ...