In addition to its better-known role in regulating pituitary function, CRH also may participate as a neurotransmitter acting centrally to enhance sympathetic activation of the adrenal medulla. Many experimental models of stress have been evaluated that reliably activate the HPA axis and the sympatho-...
The brain then reduces the production of the neurohormones that are telling the adrenal glands to produce more stress hormones. What is the HPA axis and what does it do? The HPA axis is an abbreviation for the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis is part of the ...
Dysfunction of the hypothalamic–pituitary–adrenal (HPA)-axis has been observed in chronic alcoholics and in non-alcoholic sons of alcoholic parents, while genetic and environmental factors, such as stress, may play a significant role in the development of alcoholism. The present study was designed...
Starting week 4, the animals were given either a low dose (60mg/kg) or high dose (300mg/kg) of metformin in drinking water. In addition to body weight and feeding, we examined different arms of the HPA axis to test if metformin can reinstate its function and coupling. To understand ...
A longitudinal study on hypothalamus-pituitary-adrenal (HPA) axis activity in transgender individuals. Psychoneuroendocrinology. 2019;104:228–37. CAS PubMed Google Scholar Colizzi M, Costa R, Todarello O. Transsexual patients’ psychiatric comorbidity and positive effect of cross-sex hormonal ...
Proinflammatory cytokines, such as IL-6, TNFα, and IL1-β represent crucial mediators shown to drive the abnormal function of the HPA axis in chronic-stress disorders. Consistent with this finding proinflammatory cytokines have been shown to play a crucial role in HPA axis deregulation in MD,...
HPA Axis Function During the Perinatal Period in Patients with Affective Disorders Abnormal function of the hypothalamicpituitaryadrenal (HPA) axis along with the sympathetic-adrenalmedullary (SAM) axis represents the hallmark pathologica... M Flores-Ramos,MLM Gomez,RG Bustos,... - 《Post Communist ...
aThis effect has been observed in the absence of laboratory evidence of HPA axis suppression, suggesting that growth velocity is a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis function. 这个作用在没有HPA轴镇压时的实验室...
a332 evidence of HPA axis suppression, suggesting that growth velocity is a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis function. 332 HPA轴镇压的证据,建议成长速度比HPA轴作用一些常用的测试是系统类皮质激素曝光更加敏感的显示...
Acute and long-term treatments with the selective serotonin reuptake inhibitor citalopram modulate the HPA axis activity at different levels in male rats. It is well established that the maximal therapeutic effect of selective serotonin reuptake inhibitors (SSRI) are achieved in depressive patients after...