acholesterol is the precursor of vitamin D3,or cholecalciferol,which is required for the normal function of calcium and phophate metabolism 胆固醇是维生素D3前体或者cholecalciferol,为钙和phophate新陈代谢的正常功能需要[translate]
CONCLUSIONS: Calcineurin overexpression leads to development of a hyperdynamic phenotype with a cellular profile of increased calcium influx. This type of functional hypertrophic remodeling is accompanied by a negative feedback regulation between increased calcium handling and beta-adrenergic contractile ...
Carafoli, both pioneers in the field of calcium signalling. I am very grateful to the many excellent young scientists who I have had the pleasure to work with over the years; without them it would not have been possible to establish the function of nuclear calcium in biological adaptations. ...
Objective: Activating mutations in the calcium-sensing receptor (CASR) gene cause autosomal dominant hypoparathyroidism, and heterozygous inactivating CASR mutations cause familial hypocalciuric hypercalcemia. Recently, there has been a focus on the use of allosteric modulators to restore the functional ...
Indeed, we demonstrate that megakaryocytes express the major candidates to mediate Store-Operated Calcium Entry, stromal interaction molecule 1, Orai1 and canonical transient receptor potential 1, which are activated upon either pharmacological or physiological depletion of the intracellular calcium pool. ...
Auxiliary α2δ subunits regulate the current density and the kinetics of voltage-gated calcium channels (VGCCs). Of the four α2δ isoforms known, three (α2δ-1, -2, -3) are expressed in the central nervous system. For example, α2δ-2 mutants suffer from severe neurological phenotypes...
Schwartz A, Petrashevskaya NN (2001) The importance of calcium in interpretation of NaK-ATPase isoform function in the mouse heart. Cardiovasc Res 51:9... A Schwartz,NN Petrashevskaya - 《Cardiovascular Research》 被引量: 93发表: 2001年 The importance of calcium in interpretation of NaK-ATPa...
Moreover, female cardiac mitochondria have a greater mitochondrial calcium retention capacity compared with males [43]. Therefore, sexual dimorphism of cardiac mitochondria may contribute to differences in the temporal development of cardiometabolic and cardiac autonomic impairments as shown in the present ...
As well, the extreme carboxy-terminus has a small sequence stretch related to the other PRRs and CONSTANS (CO)-like proteins, and this peptide stretch has been termed the CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain. 展开 关键词: Escherichia coli Transformation, Bacterial Plasmids Calcium ...
Platelet-active drugs are of potential benefit in prevention of diabetic microangiopathy as well as other thromboembolic complications. The present investigation examines the effect of an angio-protective agent, calcium dobesilate (Doxium) on platelets and suggests its mechanism of action. Calcium dobesil...