Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A. 2009; 106 :18704–18709.Mattes, J., Collison, A., Plank, M., Phipps, S. & Foster, P.S. (2009) Antagonism of microRNA-12...
Although it is known that progranulin (PGRN) induces the production of Th2 cytokines in iNKT cells in vivo, the underlying mechanism is not clear. This study aims to investigate the role of PGRN in iNKT cells. The effects of PGRN on the differentiation of iNKT cells was detected by flow ...
TH2 cells predominantly secrete interleukin (IL)-4 and IL-13, potent pro-inflammatory cytokines that play critical roles in allergic diseases such as asthma23,24. Two unique receptors utilize the IL-4 receptor a (IL-4Ra) chain: The type 1 receptor is composed of a heterodimer of the IL-...
IL-4 was used as a marker of TH2 effector function and measured by flow cytometry. Activation of TH2 cells increased NKG2A positivity from (Mean ± SE) 7.3 ± 2.4% to 13.7 ± 3.8%; (p = 0.03). The presence of NKG2A agonist did not significantly alter NKG2A expression, however, ...
Immune tolerance at maternal-fetal interface is the basis for establishment and maintenance of successful pregnancy. T cells are pivotal compositions of uterine decidual immune cells, which are required to mediate anti-infection immunity and protect embryos from external antigens attack. T cells also ...
Adult T-cell leukemia-lymphoma (ATL) is a distinct malignancy of CD4+/CD25+/CCR4+/FoxP3+ or- Treg/TH2 cells etiologically associated with human T-cell lymp... L Dahmoush,Y Hijazi,E Barnes,... - Springer Berlin Heidelberg 被引量: 59发表: 2002年 A phase II study of bortezomib in ...
Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proceedings of the National Academy... J Mattes,A Collison,M Plank,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 0发...
EGFR expression on Th2 cells was TCR-signaling dependent, and therefore, our data reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation. Graphical Abstract Mice lacking EGFR expression on Tcells are more susceptible to worm...
aT cells can be classified into Th, CTL and Treg subtypes by their function.Depending on the capabilities to produce cytokines, Th can be divided to Th1,Th2, Th3, Th9, Th17, Th22 and Tfh subtypes t淋巴细胞可以被分类入Th、CTL和Treg子型由他们的作用。根据生产cytokines的有能力, Th可以被划...
The aim of this study was to compare functional activities of CD8+ T cell clones producing Th1-type (Tc1) or Th2-type (Tc2) cytokines derived from peripheral blood mononuclear cells of HIV-seropositive individuals and to evaluate if Tc2 cells are able to favor disease progression. CD8+T ce...