How additional transcription factors regulate the function of Th1 cells has not been defined. In this study we show that the negative regulatory factor Twist1 decreases expression of T-bet, Runx3, and IL-12Rβ2 as it inhibits IFN-γ production. Ectopic expression of Runx3, but not T-bet ...
We showed that overexpression of miR-146a in PBMCs could significantly upregulate the function of Th1 cells. Furthermore, we showed that miR-146a treatment could modulate the Th1 differentiation through posttranscriptional enhancing the T-bet pathway in PBMCs. In addition, this study also provided ...
Th1 cell anergy and blockade in G1a phase of the cell cycle. In further support of this hypothesis, HLA-A1–specific T cells repeatedly stimulated in vitro with antigen to emulate possible autoimmune responses converted to effector/memory phenotype cells resis... KM Gilbert,WO Weigle - 《Journal...
Sleep can promote the activation of Th1 cells, increase the production of IFN-γ and other related cytokines, thereby enhancing the ability to combat intracellular viruses and bacteria. At the same time, sleep can inhibit the release of cortisol, promote the release of growth hormone and ...
Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. Murine Th1 and Th2 subsets differ not only in the lymphokines they produce, but also functionally. It is not clear what factors influence the preferential ... Fernandez-Botran,R. - 《...
内容提示: Antigen Experience Shapes Phenotype and Function ofMemory Th1 CellsAaruni Khanolkar 1,2¤ , Matthew A. Williams 2 *, John T. Harty 1,3,4 *1Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America, 2Department of Pathology, University of Utah, ...
TH1 cells, IL-12-dependent activation of Signal Transducer and Activator of Transcription 4 (STAT4) drives the expression of the transcriptional regulator T-bet and expression of the TH1 gene program, while IL-6- or IL-21-dependent activation of STAT3 and up-regulation of the transcriptional ...
Th17cells are suggested to be pathogenic in mediating experimental autoimmune encephalomyelitis (EAE), but their relation to interferon (IFN)-γ-producing Th1 cells in vivo is not well understood. We studied the numbers and functions of Th17 cells in CREAE in Biozzi ABH mice, both in peripheral...
Here, we establish that IFN-β inhibits mouse IFN-γ+ Th1 cell function in the absence of APCs. CD4+ T cells express the type I interferon receptor, and IFN-β can suppress Th1 cell proliferation under APC-free stimulation conditions. IFN-β-treated myelin antigen-specific Th1 cells are ...
cells by promoting the release of immunomodulatory cytokines such as IL-27 from antigen-presenting cells (APCs), its direct effects on inflammatory CD4+Th1 cells are less clear. Here, we establish that IFN-β inhibits mouse IFN-γ+Th1 cell function in the absence of APCs. CD4+T cells ...