Endogenous human growth hormone (GH) modulates the effect of gonadotropin-releasing hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic mice bearing human G... E. Wagner. Endogenous human growth hormone (GH) modulates ...
Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome Mild hypoandrogenism in men, usually defined by low levels of testosterone, is a peculiar feature of abdominal obesity that independently predicts the...
However, once the sex hormones dissociate from SHBG, they can escape the blood stream, and bind with the intracellular androgen or estrogen receptors, causing changes in gene expression of cells [17]. It is thus generally accepted that only the non-bound hormone is biologically active [23]. ...
THE TROPHIC FUNCTION OF TESTOSTERONE ON HORMONE SENSITIVE SKELETAL MUSCLESThe pharmacology of serjanosides, active principles isolated from the fish-poison plant Serjania lethalis St. Hil, a Sapindaceae, was investigated by comparing their actions in fishes and mammals with those of rotenone and ...
Disruption can occur in all stages of hormonal regulation: 1. hormone synthesis; 2. hormone release and storage; 3. hormone transport and clearance; 4. hormone receptor recognition and binding; 5. hormone postreceptor activation; 6. the thyroid function; and 7. the central nervous system. ...
assay techniques and inclusion criteria. Proposed mechanisms for an age-associated decline in testosterone production include: (i) defects in the hypothalamic-pituitary-testicular axis; (ii) an increase in sex hormone binding globulin levels; (iii) environmental factors; (iv) medication use; and (v...
Detection of sex hormones (testosterone, follicle- stimulating hormone, luteinizing hormone, prolactin, estra- diol and inhibin B) showed a high follicle-stimulating hormone and prolactin level, and low inhibin B level (Supplementary Table S1). Testis size, semen analysis, and hormone detection all...
It has also been shown that hormone replacement therapy as well as therapy using SERM can have a positive effect on skin aging [95], [96], [97]. Several other studies have linked the loss of ELC with the prolapse of pelvic organs [98], [99], a process highly associated with the ...
As previously shown13, male AROM+ mice have significantly higher estradiol and lower testosterone levels compared to wild type (WT) male mice. Furthermore, pharmacological inhibition of the aromatase activity resulted in the anticipated normalization of the hormone levels (Fig. 1A). Thus, the male...
Estradiol and dihydrotestosterone (DHT) are steroid hormones that regulate vertebrate reproduction and are synthetized from testosterone. Thesrd5a1-3genes encode enzymes involved in the conversion of testosterone to DHT, the most potent androgen in tetrapods, while cytochrome P450 19A1 (cyp19a1oraromat...