Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a molecular understanding of its function in normal cells and how it impedes cancer development has been challenging. Historically, the ability of RB to regulate the cell cycle placed it in a central ...
OPEN Citation: Cell Death and Disease (2017) 8, e3037; doi:10.1038/cddis.2017.394 Official journal of the Cell Death Differentiation Association www.nature.com/cddis Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis Xiao Chen1...
Because cGMP-dependent protein kinase (PKG) is an... RB Thorpe,MC Hubbell,S Jinjutha,... 被引量: 0发表: 2020年 Eastern Mediterranean migrations of Pieris rapae (Linnaeus, 1758) (Lepidoptera: Pieridae): observations in Cyprus, 2001 and 2007 Observations of migratory butterfly activity within...
A more definitive examination will require a “knock in” of a mutation that completely abolishes the kinase activity, for example, a mutation in the ATP binding pocket such as K375M. In general, since residual expression of incomplete C-Raf transcripts coding for various C-Raf protein ...
Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the “male–female health-survival paradox”. Sex hormones may be one of the
In both tumour tissues and breast cancer cell lines, the abundance of this protein shows characteristic variations consistent with a cell-cycle oscillation and the peak levels expressed in G1. In all 7 cell lines whose retinoblastoma (Rb) protein is mutant or complexed to SV40 T antigen, ...
Ferroptosis is a newly defined form of regulated cell death (RCD) characterized by iron overload, lipid reactive oxygen species (ROS) accumulation, and lipid peroxidation, which is different from necrosis, apoptosis, autophagy and other forms of RCD in morphology, biochemistry, function and gene ex...
Defects in RNA-binding protein (RBP) functions, especially RBPs that are involved in alternative splicing, have, however, emerged as a common theme in a number of neurodegenerative disorders, including spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Frontotemporal lobar dementia ...
As p53 is such a potent inhibitor of cell growth, its function must be tightly controlled to allow normal growth development. This is achieved through several mechanisms that include regulation of p53 transcription and translation, protein stability, subcellular localization and activity [19]. Rapid ...
S1C). To test the effectiveness of our cKO strategy, fibroblast cells from homozygous Rbm8afl/fl mice were infected with an RFP-cre virus in vitro. RBM8A protein was absent in RFP-positive cells (cre+, white arrowheads), but still expressed in RFP-negative cells (blue arrowheads; ...