The RasGRP3, an activator of H-Ras and R-Ras protein exerts oncogenic effects and the overexpression of the protein is observed in numerous malignant cancer types. Here, we investigated the putative alteration of expression and potential function of RasGRP3 in the formation and progression of ...
A HUMAN PROTEIN, SELECTED FOR ITS ABILITY TO INTERFERE WITH RAS FUNCTION, INTERACTS DIRECTLY WITH RAS AND COMPETES WITH RAF1 来自 ResearchGate 喜欢 0 阅读量: 6 作者:LM HAN,J COLICELLI 摘要: The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger family of at ...
This article is cited by The ancestral type of the R-RAS protein has oncogenic potential Antea Talajić Kristina Dominko Helena Ćetković Cellular & Molecular Biology Letters (2024)Download PDF Sections Figures References Abstract Introduction Results Discussion Conclusions Methods Data ...
Rab GTPases, as the largest branch of the Ras superfamily of proteins, function as regulators of vesicle transport, protein trafficking, membrane targeting and fusion. In humans, there are more than 70 different Rab proteins that are localized to distinct intracellular membranes (Schwartz et al.20...
Understanding protein function is pivotal in comprehending the intricate mechanisms that underlie many crucial biological activities, with far-reaching implications in the fields of medicine, biotechnology, and drug development. However, more than 200 mi
Rapid induction of p53 function is achieved in response to most forms of stress through post-translational mechanisms, leading to the stabilization and activation of the p53 protein. Allowing normal proliferation The induction of p53 in response to oncogenes such as Myc, Ras and E2F1 provides an ...
Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alternatively spliced, it was not clear, whether the frequency of alternative splicing is the same in different functional categories. The ...
Moreover, no evidence has been provided to suggest that the nucleotide status of Rnd proteins can be influenced by GEFs and GAPs. Instead, the activity of Rnd proteins may be regulated at the level of expression as demonstrated by the finding that Ras and the Ras-activated Raf-MEK-ERK ...
Table 4.1 lists all 20 proteinogenic amino acids present in peptides which interact with MHC molecules. There are different criteria for grouping amino acids, such as the size of side chains, polarity, charge or hydrophobicity. Regarding the specific cha
Furthermore, in SigR1-deficient cells the transport of vesicular stomatitis virus glycoprotein is inhibited, leading to the accumulation of this cargo protein in the Golgi apparatus. Moreover, depletion of SigR1 destabilized lipid rafts and associated calcium mobilization, confirming the crucial role ...