doi:10.1007/978-1-4612-2596-6_15Fritz MarkwardtSpringer New YorkFritz Markwardt. "The Role of Potassium Ions in the Control of Heart Function: Ion Channels and Ion Pumps" 317-348.
In contrast to the consensus notion that cardiac ATP-sensitive potassium (KATP) channels are composed of Kir6.2 as the pore-forming subunit and SUR2A as the regulatory subunit, recent studies have revealed that rodent atrial KATP channel... H Zhang,JR Silva,Y Lin,... - 《Heart Rhythm》 被...
Main Text : 2514 References: 504 ABSTRACT Purpose: Aldosterone antagonists (AA) decrease mortality in heart failure (HF) and preserve potassium lost from loop diuretic. Clinical trials also showed they worsen renal function (RF). This effect may be compounded in patients with decompensated HF (DHF...
ATP-sensitive potassium (K) channels in the heart are critical regulators of cellular excitability and action potentials during ischemia. However, little i... G Vivek,J Jiao,K Hu - 《Cardiovascular Research》 被引量: 74发表: 2008年 加载更多来源...
Results of a randomiz... To assess the anti-ischaemic and anti-arrhythmic effects and overall safety of nicorandil, an ATP sensitive potassium (K+) channel opener, with 'cardioprot... DJ Patel,HJ Purcell,KM Fox - 《European Heart Journal》 被引量: 280发表: 1999年...
Understanding mechanisms of antioxidant action in health and disease Article 15 September 2023 Pharmacological polysulfide suppresses glucose-stimulated insulin secretion in an ATP-sensitive potassium channel-dependent manner Article Open access 18 December 2019 Dietary restriction transforms the mammalian ...
The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function. Yet the biological and physiological identities and the origin of the specialized cardiomyocyte populations have not been fully comprehended. ...
Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man. To determine the sensitivity of several isovolumic and ejection phase indices of myocardial contractility to loading, inotropic stimulation and heart...
Aristotle considered the heart to be the body's furnace, radiating energy in the form of heat14. Given the astounding energetic cost of cardiac function, this concept is not so far from the truth. Humans produce and consume roughly their body weight in ATP (about 65 kg) every single day15...
Cardiomyocytes derived from human embryonic stem (hES) cells potentially offer large numbers of cells to facilitate repair of the infarcted heart. However, this approach has been limited by inefficient differentiation of hES cells into cardiomyocytes, in