Context: P-selectin is a promising target for inflammatory-related diseases. Polysaccharides are the active ingredients of Sanguisorba officinalis L. (Rosaceae) responsible for its anti-inflammatory activities; however, the molecular mechanism is not clear yet.Objective: This study evaluates the effects ...
Inhibitory function of P-selectinmediated leukocyte adhesion by the polysaccharides from Sanguisorba officinalis. Tong H,Song J,Zhang Z,et al. Pharmaceutical Biotechnology . 2015Tong H, Song J, Zhang Z, et al. Inhibitory function of P-selectin-mediated leukocyte adhesion by the polysaccharides from...
包含该表、视图或昵称的模式的 SELECTIN 特权 包含该表、视图或昵称的模式的 DATAACCESS 权限 对于数据库的 DATAACCESS 权限 对于CREATE FUNCTION 语句中指定的任何表或视图,不考虑 PUBLIC 以外的组特权。 调用函数时,将应用昵称所引用的表或视图的数据源的授权需求。 该连接的授权标识可以映射到不同的远程授权标识...
Thus, they are thought to be an important component for the skin-homing capacity of CD8+ T cells. Mice deficient in E- and P-selectin or their ligands have reduced skin-homing CD8+ T cells in vaccinia virus–infected skin. In addition, blocking the antibody to E- and P-selectin ...
While the PAR-injection reduces the extent of aggregation by 46%, platelets of cocaine-injected mice showed 34% elevation (Fig. 3A and Table 1). The level of P-selectin on the platelet surface is a good marker for their shift from the resting stage. Therefore, the surface expression of ...
Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur J Immunol 1998; 28:80-89.Ruchaud-Sparagano MH, Drost EM, Donnelly SC, Bird MI, Haslett C, Dransfield I. Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur J Immunol 1998...
, 26.. More recently, additional technologies have been used, including flow cytometry for the measurement of platelet glycoproteins and P‐selectin, a marker of α‐granule secretion 26. Certain groups have also made particular use of electron microscopy to identify defects in platelet morphology ...
Further investigations were conducted to show that CD146+ cells [75, 76] were self-regulated of very late antigen-4 (VLA-4) and in combination with p-selectin glycoprotein ligand-1 (PSGL-1)-mediated progressing of these cells. Galectin-1 (LGAL-1) and galectin-3 (LGAL3) have been ...
6 Other tests used to study platelet function in clinical research settings include plasma assays for platelet factor 4, β-thromboglobulin, and soluble P-selectin,7, 8, 9 plasma and urine assays for thromboxane A2 metabolites,10, 11 and the Wu and Hoak method for the detection of circulating...
Super-resolution imaging has also illuminated the transient nanoscale reorganization of surface proteins critical for leukocyte function, such as CD44 clustering during cell rolling over E-selectin, which is a key step in the leukocyte extravasation process [74]. This level of detailed visualization off...