Ligand-gated ion channels are transmembrane proteins that respond to a variety of transmitters, including acetylcholine, 纬-aminobutyric acid (GABA), glycine, and glutamate [ 1, 2]. These proteins play key roles in neurotransmission and are typically found in the nervous system and at neuromuscular...
As in the case of many ligand-gated ion channels, the biochemical and electrophysiological properties of the ionotropic glutamate receptors have been studied extensively. Nevertheless, we still do not understand the molecular mechanisms that harness the free energy of agonist binding, first to drive ch...
Baenziger, The M4 transmembrane α-helix contrib- utes differently to both the maturation and function of two prokaryotic pentameric ligand-gated ion channels, J. Biol. Chem. 290 (2015) 25118-25128.C.M. Henault, P.F. Juranka, J.E. Baenziger, The M4 transmembrane α-Helix contrib- utes...
Insect olfactory receptors are heteromeric ligand-gated ion channels. In insects, each olfactory sensory neuron expresses between one and three ligand-binding members of the olfactory receptor (OR) gene family, along with the... K Sato,M Pellegrino,T Nakagawa,... - 《Nature》 被引量: 1294...
Recent research on various ion channel proteins have revealed that they can be classified into several groups of super-families from their structural similarity. Among them, the voltage-gated ion channel super-family, including K(+)-channel, Na(+)-channel and Ca(2+)-channel, consist of four ...
X-ray structure of a prokaryotic pentameric ligand-gated ion channel Nature, 452 (2008), pp. 375-379 Google Scholar Hilf and Dutzler, 2009 R.J.C. Hilf, R. Dutzler Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel Nature, 457 (2009), pp. ...
Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to ...
Previous studies suggest that serine 296 (S296) in the third transmembrane domain of the GlyR α1 subunit critically contributes to the cannabinoid-GlyR interaction (Xiong et al., 2011; Lu et al., 2018). Show abstract Effects of cannabinoids on ligand-gated ion channels 2022, Frontiers in ...
Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system and have been characterized as potent proton sensors to ...
Glycine receptor (GlyR)2 chloride channels mediate fast inhibitory neurotransmission in the spinal cord, brainstem, and retina, and are thus essential for controlling motor and sensory function (1., 2., 3.). Like other members of the pentameric ligand-gated ion channel family, GlyRs are assembl...